抗环瓜氨酸肽抗体对类风湿关节炎的诊断及与骨侵蚀相关性研究  

The value of Anti-cyclic citrullinated peptide antibodies in diagnosis of rheumatoid arthritis and its correlativestudy for bone erosion

作　　者：梁鹏[1] 安宏亮[1] 张劲丰[1] 李璐[1] 郑宝林[2] 陈兴明[3] 

机构地区：[1]佛山市中医院检验科,广东佛山528000 [2]佛山市中医院风湿科,广东佛山528000 [3]佛山市中医院放射科,广东佛山528000

出　　处：《中国卫生检验杂志》2015年第1期62-64,共3页Chinese Journal of Health Laboratory Technology

基　　金：2014年度佛山市卫生局医学科研立项课题(2014128)

摘　　要：目的探讨抗环瓜氨酸肽抗体(Anti-CCP)对类风湿关节炎(RA)诊断的意义及与骨侵蚀相关性研究。方法选取266例RA患者进行血清Anti-CCP、类风湿因子(RF)的含量及手足X线摄片检测。结果 Anti-CCP对RA诊断特异度为90.32%,灵敏度为96.53%,RF特异度为76.34%,灵敏度为94.22%,Anti-CCP与RF相比在灵敏度方面相当,但在特异度方面Anti-CCP具有明显优势。RA患者Anti-CCP与骨侵蚀的相关系数r=0.823,P<0.001,两者差异有统计学意义,成高度正相关关系;RF水平与骨侵蚀的相关系数为r=0.248,P<0.05,两者差异有统计学意义,成低度正相关关系。结论 Anti-CCP对RA诊断具有很高的特异度,有助于早期RA及RF阴性RA的诊断,并可用于区分RA和其他RF阳性骨关节炎症。Anti-CCP与RA骨侵蚀呈高度正相关,Anti-CCP较RF对骨侵蚀具有更好的预测价值。Objective To explore the diagnostic significance of Anti- cyclic citrullinated peptide antibodies for rheumatoid arthritis（ RA） and its correlative study for bone erosion. Methods The study population comprised 266 patients with RA,and serum Anti- CCP,rheumatoid factor（ RF） content and X- ray detection of hands and feet were tested. Results The specificity and sensitivity of Anti- CCP and RF were respectively 90. 32%,96. 53%; 76. 34%,94. 22% for the diagnosis of RA. The sensitivity of these indicators were almost the same for Anti- CCP and RF,but the specificity of Anti- CCP had the obvious advantages. The correlation coefficient between Anti- CCP and bone erosion is r = 0. 823,P〈0. 001. The difference between them had statistical significance and there was highly positive correlation between them. The correlation coefficient of RF is r =0. 248,P〈0. 05. The difference between them had statistical significance and positive correlation is low. Conclusion The specification of Anti- CCP was high for RA diagnosis,and helpful at the early stage of RA and while the indicator of RF was negative. It also can be used to distinguish RA and other negative RF osteoarthritis disease. Anti- CCP was highly correlative with bone erosion degrees,and the predictive value of Anti- CCP was better than RF.

关 键 词：抗环瓜氨酸肽抗体 类风湿因子 骨侵蚀 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]