葛根芩连片主要活性成分的溶解度及油水分配系数的测定  

Determination on Solubility and Oil-water Partition Coefficient of Main Active Components in Ge-Gen Qin-Lian Tablets

作　　者：朱美玲[1] 刘洋[1] 曹燕飞[1] 隗丽[1] 唐明敏[1] 杨文宁[1] 侯成波[1] 魏宝霞[1] 靳梦亚 董玲[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《世界科学技术-中医药现代化》2014年第12期2686-2699,共14页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：北京中医药大学创新团队发展计划资助项目(2011-CXTD-13):基于经典方的中药生物药剂学分类系统的构建研究;负责人:董玲

摘　　要：目的:测定葛根芩连片中主要活性成分(葛根素、黄芩苷和盐酸小檗碱)及其在复方多成分环境下,于不同p H磷酸缓冲液中的溶解度及油水分配系数。方法:采用HPLC法测定葛根素、黄芩苷和盐酸小檗碱在不同p H介质中的溶解度,以及在正辛醇-水和正辛醇-缓冲液体系中的油水分配系数。结果:葛根素、黄芩苷和盐酸小檗碱的溶解度与油水分配系数随p H的变化而变化,在复方多成分背景下也会发生改变。在p H为7.4时溶解度最大,葛根素为7.56 mg·m L-1,黄芩苷为17.07 mg·m L-1,盐酸小檗碱为3.57 mg·m L-1;3者油水分配系数P在p H为1.0时较大,葛根素为0.420(lgP=-0.38),黄芩苷为10.783(lgP=1.03),盐酸小檗碱为0.267(lgP=-0.57)。结论:葛根素、黄芩苷和盐酸小檗碱在p H为1.0时脂溶性均较好,推测在胃里吸收较好,在其它p H介质下脂溶性较低,推测脂溶性可能是影响其肠吸收的原因之一。Comorbidity, which can affect the treatment and prognosis of its disease, has gradually caught attention from both at home and abroad. Although chronic obstructive pulmonary disease （COPD） mainly involved lung tissues, it may also cause the systemic （or extra-pulmonary） adverse effects. Many types of comorbidities existed in COPD. This article summarized the prevalence, risk factors and pathogenesis of comorbidities such as cardiovascular disease, osteoporosis, anxiety and depression, lung cancer, infection, metabolic syndrome and diabetes mellitus. It also conducted related studies on the diagnosis and treatment status and current problems of COPD comorbidities, which may provide evidences for COPD outcome evaluation.

关 键 词：葛根芩连片 葛根素黄芩苷 盐酸小檗碱 溶解度 油水分配系数 

分 类 号：R284.1[医药卫生—中药学]