淫羊藿苷对离体大鼠胸主动脉环舒缩功能和左心室内压的影响  

The Effect of Icariin on the Vasorelaxant Function of Isolated Rat Thoracic Aortic Rings and the Pressure of Left Ventricle

作　　者：鲍京[1] 丁选胜[1] 

机构地区：[1]中国药科大学临床药学教研室,南京210009

出　　处：《药学与临床研究》2015年第1期5-8,共4页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金(81274158)

摘　　要：目的:研究淫羊藿苷体外给药对大鼠离体胸主动脉环舒缩功能和左心室内压的影响以及其可能的机制。方法:取正常大鼠胸主动脉和心脏,制成胸主动脉环和完整的离体心脏,观察不同浓度淫羊藿苷对胸主动脉环张力和左心室内压的影响。结果:淫羊藿苷能够剂量依赖性的舒张内皮完整的胸主动脉环,降低胸主动脉环的收缩张力,L-硝基精氨酸(NLA)能够减弱淫羊藿苷的舒血管作用。淫羊藿苷还能够降低离体大鼠心脏左心室收缩峰压(LVSP)、最大上升速率(+dp/dt)。结论:淫羊藿苷能舒张离体胸主动脉环,降低心脏收缩力,并且其舒血管效应与内皮和一氧化氮(NO)相关。Objective： To investigate the effectof icariin （ICA） on the vasorelaxant function ofisolated rat thoracic aortic rings, the pressure ofleft ventricle （LV） and the underlying mechanism.Methods： The thoracic aortas and hearts were re-moved to make thoracic aortic rings and isolatedhearts. The effect of icariin on the diastolic andsystolic function of the isolated thoracic aorticrings and hearts were observed. Results： The tho-racic aortic rings with intact endothelium relaxed,the left ventricular systolic pressure （LVSP） andmaximum rate of pressure rise （＋dp/dtmax） were de-creased by icariin in a dose -dependent manner.The systolic effect of icariin on aortic rings couldbe reduced by pre -treating with nitro -L -arginine（NLA）. Conclusion： The results suggested that i-cariin decreased LVSP and ＋dp/dtmax, relaxed iso-lated rat thoracic aortic rings. Endothelium and ni-tric oxide （NO） might be responsible for the relax-ation effect.

关 键 词：淫羊藿苷 内皮 血管张力 一氧化氮 

分 类 号：R965.1[医药卫生—药理学]