盐酸莫西沙星注射液和苦参碱注射液配伍稳定性考察  

The Compatible Stability Study of Moxifloxacin Hydrochloride Injection and Matrine Injection

作　　者：王丽莉[1] 李叶丰[1] 王娴[1] 魏媛怡 潘莉[1] 王春霞[1] 

机构地区：[1]南方医科大学南方医院药学部,广东广州510515

出　　处：《药品评价》2014年第22期21-23,29,共4页Drug Evaluation

基　　金："盐酸莫西沙星氯化钠注射剂配伍稳定性研究"。2013年中日医学科技交流协会"药品质量评价与用药安全"项目;本项目无编号

摘　　要：目的:考察莫西沙星注射液和苦参碱注射液的配伍稳定性,为临床用药安全提供实验依据。方法:模拟临床常用浓度和配制方法,观察莫西沙星注射液和苦参碱注射液配伍后,在8h内配伍液的外观、p H值,并采用高效液相色谱法(HPLC)测定其含量变化。结果:配伍溶液的外观和p H值无明显变化,苦参碱和盐酸莫西沙星8h内其相对百分含量无明显变化。结论:在25℃和37℃下,苦参碱和盐酸莫西沙星配伍后8h内是稳定的。Objective： To investigate the compatibility and stability of moxifloxacin hydrochloride injection and matrine injection, to provide an experimental basis for clinical drug safety. Methods：According to the common concentration and preparation methods used in clinic, the appearance and PH value were observed; the concentrations were determined by HPLC after combination of morxifloxacin hydrochloride injection and matrine injection within 8 hours. Results： The appearance and PH of compatibility solution had no significant changes and its relative contents did not change markedly within 8 hours. Conclusion：The compatibility of moxifloxacin hydrochloride injection and matrine injection within 8h is stable at 25℃and 37℃.

关 键 词：高效液相色谱法 莫西沙星注射液 苦参碱注射液 配伍稳定性 

分 类 号：R969.2[医药卫生—药理学]