氟伐他汀对早期糖尿病肾病患者炎症因子及疗效的影响  

Influence of Fluvastatin on Inflammation Factors and Therapeutic Effect in Patients with Early Diabetic Nephropathy

作　　者：余红梅[1] 刘新云[2] 

机构地区：[1]湖北医药学院附属太和医院内分泌科,湖北十堰442000 [2]桂林医学院附属医院药学部

出　　处：《中国药师》2015年第2期271-272,279,共3页China Pharmacist

摘　　要：目的:观察氟伐他汀对早期糖尿病肾病患者高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、尿微量白蛋白排泄率(UAER)和血清肌酐(Cr)的影响。方法:69例早期糖尿病肾病患者随机分为观察组34例(低蛋白饮食+氟伐他汀)和对照组35例(低蛋白饮食),两组患者疗程均为8周,分别于治疗前后检测hs-CRP、TNF-α、UAER、ALT、Cr水平,并与同期另设的正常组65例的上述指标水平进行比较。结果:与治疗前相比,对照组治疗后UAER水平明显下降(P<0.05);hs-CRP、TNF-α水平下降不明显(P>0.05);观察组治疗后UAER、hs-CRP、TNF-α水平均明显下降(P<0.05或0.01),且明显低于低于对照组同期(P<0.05或0.01)。两组治疗前后ALT、Cr变化差异无统计学意义(P>0.05),但治疗8周时观察组Cr明显低于对照组(P<0.05)。观察组、对照组在治疗前后UAER、hs-CRP、TNF-α均明显高于正常组(P<0.05);ALT、Cr与正常组比较差异无统计学意义(P>0.05)。结论:UAER、hs-CRP、TNF-α与糖尿病肾病密切相关,氟伐他汀与低蛋白饮食联合治疗早期DN,可显著抑制炎症因子hs-CRP、TNF-α,降低UAER。Objective： To investigate the effects of fluvastatin on high-sensitivity c-reactive protein（ hs-CRP）,tumor necrosis factor-α（ TNF-α）,urine albumer excretion rate（ UAER） and serum creatinine（ Cr） in the patients with early diabetic nephropathy.Methods： Totally 69 patients with early diabetic nephropathy were randomly divided into the observation group with 34 cases and the control group with 35 cases. The observation group was treated by low-protein diet plus fluvastatin,and the control group was treated by low-protein diet only. The course of treatment was 8 weeks. Totally 65 nondiabetic persons were selected as the normal group,and the levels of TNF-α,hs-CRP,UAER,ALT and Cr were detected before and after the treatment. Results： The levels of TNF-α,hs-CRP and UAER in the observation group and the control group were significantly higher than those in the normal group（ P 0. 05）; the levels of ALT and Cr showed no significant differences（ P 0. 05）. Compared with that before the treatment,the level of UAER was decreased significantly in the control group after the treatment（ P 0. 05）,and the levels of TNF-α and hs-CRP showed no significant differences after the treatment（ P 0. 05）. In the observation group,the levels of TNF-α,hs-CRP and UAER were all decreased significantly after the treatment（ P 0. 05）. Conclusion： UAER,hs-CRP and TNF-α are closely connected with diabetic nephropathy.Fluvastatin can decrease the levels of TNF-α,hs-CRP and UAER. Low-protein diet plus fluvastatin is effective and safe in the treatment of early diabetic nephropathy,and the efficacy is superior to that of low-protein diet only.

关 键 词：氟伐他汀 早期糖尿病肾病 高敏C-反应蛋白 肿瘤坏死因子-α 尿微量白蛋白排泄率 

分 类 号：R972.6[医药卫生—药品]