重组人酸性成纤维细胞生长因子治疗浅Ⅱ度烧伤的多中心Ⅳ期双盲、阳性药物、随机对照试验  

Ⅳ multicenter randomized positive drug controlled clinical trial of aFGF and bFGF in treatment with shallow Ⅱ burns

作　　者：钟宇 陈秋玲 李伟[3] 赵鹏[4] 侯志松[5] 甄电伟 

机构地区：[1]成都第二人民医院烧伤科,四川成都610017 [2]南京公安消防医院烧伤科,江苏南京210008 [3]中国人民武装警察部队河北省总医院烧伤科,河北石家庄050000 [4]中国人民解放军第二六零医院烧伤科,河北石家庄050047 [5]沧州市中心医院烧伤科,河北沧州061014 [6]保定第五医院烧伤科,河北保定071051

出　　处：《中国医学工程》2014年第12期11-12,共2页China Medical Engineering

摘　　要：目的比较重组人酸性成纤维细胞生长因子(rh-a FGF)与碱性成纤维细胞生长因子(b FGF)治疗浅Ⅱ度烧伤的临床疗效差异。方法入选6个研究医院254例门诊浅Ⅱ度烧伤患者。治疗组给予银离子敷料联合a FGF(清创时清洗治疗,清创后给予喷雾治疗)。对照组给予银离子敷料联合b FGF(给药方法同a FGF)。记录创面愈合时间及愈合后的色素沉着情况。结果rh-a FGF治疗后完全愈合时间为(7.1±1.5)d,b FGF治疗后愈合时间为(9.2±1.8)d,两组随访过程中感染发生率分别为1.5%,9.2%,两组比较具有统计学差异(P>0.05)。但两组色素沉着评分分别为(2.2±1.6)分,(3.0±1.4)分,不具有统计学差异(P<0.05)。结论 a FGF可促进浅Ⅱ度烧伤愈合,预防感染,疗效优于b FGF,安全性相似。[ Objective ] To compare recombinant human acidic fibroblast growth factor （rh-aFGF） and basic differences in the clinical efficacy of a fibroblast growth factor （bFGF） treatment of superficial Ⅱ degree bums. [ Methods ] The study enrolled six outpatient hospital 254 cases of superficial Ⅱ degree burns patients. The treatment group received a silver ion dressing combined aFGF （debridement cleaning treatment, aerosol therapy given after debridement）. The control group received a silver ion dressing Joint bFGF （method of administration with aFGF）. Record pigmentation situation and heal the wound healing time after. [ Results ] rh-aFGF completely healed after treatment time was 7.1 ± 1.5 d, after bFGF treatment healing time was 9.2 ± 1.8 d, the two groups during follow-up the incidence of infection was 1.5%, 9.2%, respectively, the two groups was statistically difference （P〉0.05）. But the two groups pigmentation scores were 2.2 ± 1.6,3.0 ± 1.4 d, does not have a statistically significant difference （P〈0.05）. [ Conclusion ] aFGF can promote healing of superficial II degree bums, infection prevention, more effective than bFGF, similar safety.

关 键 词：酸性成纤维细胞生长因子 碱性成纤维细胞生长因子 浅II度烧伤 

分 类 号：R644[医药卫生—外科学]