ABO新生儿溶血病与O型血孕妇孕中期血清IgG抗A(B)抗体效价的关系分析  

Analysis in relationship between ABO hemolytic disease of the newborn and antibody titer of Ig G anti A(B) in the second trimester of the pregnant women with type O blood

作　　者：周雄飞[1] 郑君[2] 毛开新[1] 

机构地区：[1]湖北科技学院临床医学院儿科,湖北咸宁437000 [2]湖北科技学院临床医学院妇产科,湖北咸宁437000

出　　处：《实用临床医药杂志》2015年第1期85-88,共4页Journal of Clinical Medicine in Practice

摘　　要：目的分析ABO新生儿溶血病(ABO-HDN)与O型血孕妇孕中期血清Ig G抗A(B)抗体效价的关系。方法选取母婴血型不合的O型血孕妇500例,根据所产新生儿血型将孕妇分为O-A组(新生儿为A型血,n=233)、O-B组(新生儿为B型血,n=204)和O-AB组(新生儿为AB型血,n=63)。对所有纳入孕妇孕中期的血清Ig G抗A(B)抗体效价进行检测,对其中血清Ig G抗A(B)抗体效价≥1∶64的孕妇所产新生儿的ABO-HDN发病率进行比较。结果 O-A组中血清Ig G抗A(B)抗体效价≤1∶32的孕妇比例显著低于O-B组(χ2=13.658,P<0.01)和O-AB组(χ2=8.940,P=0.003),而O-B组与O-AB组无显著差异(χ2=0.050,P=0.824);3组孕妇的其他抗体效价的分布均无显著差异(χ2=0.068、0.168、2.084、4.276,P=0.967、0.920、0.353、0.118);血清Ig G抗A(B)抗体效价≥1∶512的孕妇所产新生儿的ABO-HDN发生率显著高于抗体效价为1∶64的孕妇(χ2=50.891,P<0.01)和抗体效价为1∶128的孕妇(χ2=13.697,P<0.01),血清Ig G抗A(B)抗体效价为1∶256的孕妇所产新生儿的ABO-HDN发生率显著高于抗体效价为1∶64的孕妇(χ2=35.191,P<0.01)和抗体效价为1∶128的孕妇(χ2=5.940,P=0.015),血清Ig G抗A(B)抗体效价为1∶128的孕妇所产新生儿的ABO-HDN发生率显著高于抗体效价为1∶64的孕妇(χ2=12.510,P<0.01)。结论母婴血型不合的O型血孕妇孕中期的血清Ig G抗A(B)抗体效价可能与新生儿ABO-HDN发生具有相关性,可作为反映新生儿ABO-HDN发病风险的辅助指标。Objective To analyze the relationship between ABO hemolytic disease of the newborns （ABO-HDN） and the antibody titer of IgG anti A（B） in the second trimester of the pregnant women with O blood type. Methods A total of 500 type O blood pregnant women with maternal-fetal incompatibility of blood type were selected. According to the blood type of the neonates, the pregnant women were divided into O-A group （233 newborns with A blood type）, O -B group （204 newborn with B blood type） and O-AB group （63 newborn with AB blood type）. The serum antibody titers of IgG anti A（B） in the second trimester of all pregnant women were de- tected. The incidences of ABO-HDN of the newborn delivered by pregnant women with the serum antibody titer of IgG anti A（B） ≥1 ： 64 were compared. Results The ratio of the pregnant with the serum antibody titer of IgG anti A（B）≤1 ： 32 in the O-A group was significantly lower than that in the O-B group （χ^2= 13.658, P〈0.01） and the O-AB group （χ^2=8.940, P=0.003）. There was no significant difference between the O-B group and the O-AB group （χ^2= 0. 050, P = 0. 824）. There were no significant differences in distribution of other antibodies titer of pregnant women among the three groups （χ^2= 0. 068, 0. 168, 2. 084, 4. 276, P = 0. 967, 0. 920, 0. 353, 0.118）. The incidence of ABO-HDN of the newborns delivered by the pregnant women with the serum antibody titer of IgG anti A（B）≥1：512 was significantly higher than that of the pregnant women with antibody titer of 1：64 （χ^2 = 50. 891, P〈 0.01 ） and the pregnant women with anti- body titer of 1：128 （χ^2= 13. 697, P〈0.01）. The incidence of ABO-HDN of the newborns of the pregnant women with the serum antibody titer of IgG anti A（B） of 1：256 was significantly higher than that of the pregnant women with antibody titer of 1：64 （χ^2 = 35. 191, P〈0.01 ） and the pregnant women with antibody titer of 1：128 （χ^2= 5. 940, P = 0. 015）. The incidence of ABO

关 键 词：新生儿溶血病 免疫球蛋白 效价 ABO血型 

分 类 号：R556.6[医药卫生—血液循环系统疾病]