血清免疫抑制酸性蛋白在慢性乙型病毒性肝炎患者中的表达及与预后的关系  

Expression of serum immunosuppressive acidic protein in patients with chronic hepatitis B and its relationship with prognosis

作　　者：张琳 

机构地区：[1]黑龙江省哈尔滨市传染病医院传染科,黑龙江哈尔滨150030

出　　处：《实用临床医药杂志》2015年第1期151-153,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321466)

摘　　要：目的探讨血清免疫抑制酸性蛋白(IAP)在慢性乙型病毒性肝炎(CHB)患者中的表达及其与预后的关系。方法选择CHB患者64例设为研究组,采用阿德福韦酯联合保肝或/和免疫调节治疗,另选同期健康体检者50例为对照组。比较2组血清IAP水平;观察研究组治疗后的临床疗效及不良反应发生情况,并分析IAP水平、总胆红素(TBil)及凝血酶原活动度(PTA)与预后的关系。结果治疗12个月后,研究组总有效率为87.50%(56/64)。研究组IAP水平显著低于对照组(P<0.01);治疗6、12个月后,研究组IAP水平逐渐升高,但仍低于对照组(P<0.01)。预后良好的患者治疗前血清IAP水平、TBil及PTA值与预后不良者相比,差异有统计学意义(P<0.01);治疗前血清IAP水平与PTA值呈显著正相关(r=0.396,P<0.01),与TBil呈显著负相关(r=-0.371,P<0.01)。结论 IAP水平可反映CHB患者肝功能损害程度,对判断预后具有一定参考价值,可作为常规生化检查指标。Objective To explore the expression of serum immunosuppressive acidic protein （lAP） in patients with chronic viral hepatitis B （CHB） and its relationship with prognosis. Methods Sixty-four patients with CHB were selected as research group and they were treated with adefovir dipivoxil and liver protection or/and immunoregulation. Meanwhile, fifty healthy people were se- lected as control group. Serum lAP level was compared between two groups. Clinical efficacy and adverse reactions were observed after treatment, and the relationship between IAP level, total bilirubin （TBil）, prothrombin activity （PTA） and prognosis was analyzed in the research group. Results 12 months after treatment, the overall response rate was 87.50% （56/64） in the research group. IAP level in the research group was significantly lower than that in the control group （P 〈 0.01）. 6 and 12 months after treatment, lAP level in the research group increased gradually, but was still lower than the control group （P〈 0.01）. There were significant differences in serum lAP level, TBil and PTA between two groups（P〈0.01）. Before treatment, serum IAP level was posi- tively correlated with PTA value （ r = 0. 396, P〈0.01 ）, but negatively correlated with TBil （ r = -0. 371, P〈0.01）. Conclusion lAP level can reflect the injured degree of liver function in pa- tients with CHB, and it can be used as has a a routine biochemical examination index in judgment of prognosis.

关 键 词：乙型病毒性肝炎 免疫抑制酸性蛋白 总胆红素 凝血酶原活动度 预后 

分 类 号：R512.6[医药卫生—内科学]