HPV52/58感染与女性宫内病变发生风险的相关性研究  

Study on the correlation between HPV52 /58 infection and risk of female intrauterine lesions

作　　者：范成娇[1] 李静[1] 鲁爱枝[1] 

机构地区：[1]湖北省麻城市人民医院妇产科,438300

出　　处：《中国妇幼保健》2015年第6期841-843,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨HPV52/58感染与女性宫内病变发生风险的相关性。方法：以2010年6月~2013年10月来某院进行宫内病变筛查的2 874例患者为研究对象,对其进行子宫脱落细胞学（TCT）和HPV-DNA分型检测,根据检测结果将其分为4组。对HR-HPV感染型别分布情况,HR-HPV基因型与TCT检查的相关性及HPV52/58感染与宫内病变程度的相关性进行分析。结果：检出972例（33.82%）HR-HPV感染者,其中HPV16、52、58基因型感染率相对较高;子宫内膜癌患者HPV16、52/58感染率较高,分别为65.85%、42.55%,子宫肌瘤患者HPV16、52/58感染率分别为46.95%、32.48%。HPV16、52/58在子宫内膜癌及子宫肌瘤患者中感染率高于其他HR-HPV基因型（P〈0.05）;不同的宫内病变中HPV52/58感染具有一定的差异（P〈0.05）。结论：HPV52/58感染对女性宫内病变存在一定的相关性,为其防治提供了一定的理论参考依据,值得进一步深入研究。Objective： To explore the correlation between HPV52/58 infection and risk of female intrauterine lesions. Methods：A total of 2 874 patients receiving intrauterine lesions screening in the hospital from June 2010 to October 2013 were selected as research ob- jects, uterine exfoliocytology examination and HPV - DNA genotyping were conducted, then the patients were divided into four groups ac- cording to the examination results. The correlation between distribution of HR - HPV infection types, HR - HPV genotypes and uterine exfo- liocytology examination, the correlation between HPV52/58 infection and risk of female intrauterine lesions were analyzed retrospectively. Results： A total of 972 patients （33.82%） were found with HR - HPV infection, the infection rates of HPVI6, 52, 58 were relatively high; among the patients with endometrial cancer, the infection rates of HPV16 and HPV52/58 were relatively high, which were 65.85% and 42. 55% , respectively; the infection rates of HPV16 and HPV52/58 in patients with endometriosis were 46. 95% and 32.48% , respec- tively. The infection rates of HPV16 and HPV52/58 in patients with endometrial cancer and endometriosis were statistically significantly higher than those of the other HR - HPV genotypes （ P 〈 0. 05 ） ; there was statistically significant difference in the infection rate of HPV52/ 58 among different uterine lesions （P 〈 0.05 ） . Conclusion： HPV52/58 infection is correlated with female intrauterine lesions to a certain degree, which provides a certain theoretical reference basis and deserves further researches.

关 键 词：HPV52/58感染 女性宫内病变 发病风险 相关性研究 

分 类 号：R711.32[医药卫生—妇产科学]