婴幼儿巨细胞病毒肝炎相关因素临床研究  

Clinical research on related factors of infantile cytomegalovirus hepatitis

作　　者：徐建锋[1] 肖玉凤[1] 彭淑梅[1] 王伟光[1] 李容汉[1] 

机构地区：[1]广东省妇幼保健院,广东广州510030

出　　处：《中国妇幼保健》2015年第6期886-888,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨婴幼儿巨细胞病毒（CMV）肝炎的相关因素。方法：选择2010年2月~2013年6月在广东省妇幼保健院诊治的118例CMV肝炎婴幼儿为研究对象（病例组）,选择同期118例健康婴幼儿为对照组。对婴幼儿CMV肝炎的相关因素进行分析。结果：病例组CMV肝炎患儿发病月龄以1~3月龄所占比例（70.34%）居多,病例组婴幼儿来自农村的比例较高,且病例组婴幼儿父母文化程度普遍较低,母乳CMV-DNA阳性比例（74.58%）明显高于对照组（22.88%）（P〈0.05）。病例组婴幼儿月龄、居住地、父母文化程度及母乳CMV-DNA阳性等因素和对照组相比,差异有统计学意义（P〈0.05）。婴幼儿低月龄（OR=5.367,95%CI：2.451～11.755）、居住地为农村（OR=5.778,95%CI：1.963～17.009）、母乳CMV-DNA阳性（OR=5.178,95%CI：3.963～18.009）及父母文化程度低（OR=4.962,95%CI：2.958～16.016）等4项因素和婴幼儿CMV肝炎密切相关,为婴幼儿CMV肝炎的独立危险因素。结论：婴幼儿低月龄、居住地为农村、母乳CMV感染及父母文化程度低为婴幼儿CMV肝炎的独立危险因素。加强对这些危险因素的重视和干预,可以在一定程度上减少婴幼儿CMV肝炎的发生。Objective： To explore the related factors of infantile cytomegalovirus （CMV） hepatitis. Methods： A total of 118 in- fants with cytomegalovirus hepatitis diagnosed and treated in the hospital from February 2010 to June 2013 were selected as study objects （ case group） , and 118 healthy infants during the same period were selected as control group. The related factors of infantile cytomegalovirus hepatitis were analyzed. Results： In case group, 70. 34% of the infants with cytomegalovirus hepatitis was 1 -3 months old, the proportion of rural infants was relatively high, the educational levels of parents of the infants in case group were generally low, the proportion of positive CMV - DNA in breast milk of case group was 74. 58% , which was statistically significantly higher than that of control group （ 22. 88% ） （ P 〈 0. 05 ） . There were statistically significant differences in months of age, place of residence, parental educational levels and positive rate of C MV - DNA in breast milk between case group and control group （ P 〈 0. 05 ） . Low months of age （ OR = 5. 367, 95 % CI： 2.451 - 11. 755） , living in rural area （ OR = 5. 778, 95% CI： 1. 963 - 17.009）, positive CMV - DNA in breast milk （ OR = 5. 178, 95% CI： 3. 963 - 18.009） and low parental educational levels （ OR =4. 962, 95% CI： 2. 958 - 16. 016） were closely correlated with infantile cyto- megalovirus hepatitis, which were independent risk factors for infantile cytomegalovirus hepatitis. Conclusion ： Low months of age, living in rural area, positive CMV - DNA in breast milk and low parental educational levels are independent risk factors for infantile cytomegalovirus hepatitis. Paying more attention to the risk factors and strengthening intervention can relieve the occurrence of infantile cytomegalovirus hepa- titis to a certain extent.

关 键 词：婴幼儿 巨细胞病毒 肝炎 危险因素 

分 类 号：R725.126[医药卫生—儿科]