闭经患者的细胞遗传学病因及临床特征分析  

Analysis on cytogenetic causes and clinical characteristics of patients with amenorrhea

作　　者：刘学军[1] 刘慈[1] 刘芸兰 马良[1] 

机构地区：[1]河北医科大学第二医院妇产超声诊疗科遗传室,河北石家庄050000

出　　处：《中国妇幼保健》2015年第6期918-921,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨染色体异常在原发性和继发性闭经患者中的核型分布及临床意义。方法:对309例闭经患者进行外周血淋巴细胞培养,常规制片,G显带处理(必要时C显带),染色体核型分析。结果:309例闭经患者中,染色体异常84例,异常率27.18%,主要包括X染色体非整倍体(29例)、X染色体结构异常(10例)、存在Y染色体(14例)及镶嵌体(30例),其中X染色体数目和结构异常68例,占80.95%。结论:染色体异常是闭经的重要原因,无论原发性或继发性闭经,应常规行细胞遗传学检查。Objective： To explore the distribution of karyotypes of chromosomal abnormalities in patients with primary and seconda- ry amenorrhea and the clinical significance. Methods： Lymphocytes culture, routine slice making, G - band （ C - band if necessary ） and chromosomal karyotyping analysis were performed among 309 patients with amenorrhea. Results： Among 309 patients with amenorrhea, 84 patients were found with chromosomal abnormalities, the incidence rate was 27. 18% , including 29 patients with X - chromosome aneuploid, l0 patients with X -chromosome structural abnormality, 14 patients with Y -chromosome and 30 patients with chromosomal mosaic; 68 pa- tients were found with X -chromosome numerical and structural abnormalities, accounting for 80. 95%. Conclusion： Chromosomal abnor- malities are important cause of amenorrhea, cytogenetic examination should be conducted routinely among the patients with primary and sec- ondarv amenorrhea.

关 键 词：闭经 染色体 核型 细胞遗传学 

分 类 号：R711.51[医药卫生—妇产科学]