磺丁基醚-β-环糊精对兰索拉唑的包合作用  

Inclusion Effect of Sulfobutyl Ether β-Cyclodextrin on Lansoprazole

作　　者：赵孝先[1] 李新 王菊月 赵凯 张乐 

机构地区：[1]河北医科大学第四医院,河北石家庄050051 [2]河北凯盛医药科技有限公司,河北石家庄050035 [3]江西欧氏药业有限责任公司,江西新余338004

出　　处：《中国医药工业杂志》2015年第2期167-171,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用冷冻干燥法制备兰索拉唑的磺丁基醚-β-环糊精(SBE-β-CD)包合物。差示扫描量热、红外光谱和薄层色谱分析结果显示,兰索拉唑与SBE-β-CD间存在相互作用,形成了包合物。相溶解度法研究表明,兰索拉唑的表观溶解度随SBE-β-CD浓度及p H值的增加而增大。包合物在p H 6.8介质中5 min时溶出率为93%,显著高于原药及其与SBE-β-CD的物理混合物(0.04%和6%)。The inclusion complexes of sulfobutyl ether β-cyclodextrin （SBE-β-CD） with lansoprazole were prepared by freeze-drying method. The formation of inclusion complexes were characterized by differential scanning calorimetry （DSC）, Fourier transform infrared spectroscopy （FTIR） and thin layer chromatography （TLC）. The results showed that there were interactions between lansoprazole and SBE-β-CD. The results of phase solubility test showed that the apparent solubility of lansoprazole was enhanced with the increasing of SBE-β-CD concentration and pH value. The dissolution at 5 min of the inclusion complexes was 93 % in the pH 6.8 medium, which was significantly higher than that of pure drug or physical mixture of lansoprazole and SBE-β-CD （0.04 % or 6 % ）.

关 键 词：兰索拉唑 磺丁基-β-环糊精 包合物 

分 类 号：R944.9[医药卫生—药剂学]