注射用洛铂与0.9%氯化钠注射液及5%葡萄糖注射液的配伍稳定性  

Compatibility of Lobaplatin in 0.9% Sodium Chloride Injection or in 5% Glucose Injection

作　　者：欧阳丹薇[1] 邵燕[1] 孔德云[1] 隋东虎[2] 刘潇琨 

机构地区：[1]中国医药工业研究总院上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海200040 [2]贵州益佰制药股份有限公司医学部,贵州贵阳550008 [3]海南长安国际制药有限公司注册部,海南海口570314

出　　处：《中国医药工业杂志》2015年第2期199-203,共5页Chinese Journal of Pharmaceuticals

基　　金：国家"重大新药创制"科技重大专项(2013ZX09104001)

摘　　要：洛铂溶解在0.9%氯化钠或5%葡萄糖注射液中,采用高效液相色谱法分别测定在不同温度和浓度条件下,在上述2种注射液中24 h内的药物含量变化情况。结果表明,洛铂与0.9%氯化钠注射液配伍,25、37和42℃,在4 h内均稳定;与5%葡萄糖注射液配伍,25和37℃,在2 h内均稳定。此外还证实1与0.9%氯化钠或5%葡萄糖溶液配伍长时间后均可降解产生乳酸,且随时间延长而增加。An HPLC method was used to determine the content change of lobaplatin in 0.9 % sodium chloride injection or in 5 % glucose injection stored at different temperatures and concentrations for 24 h. The results showed that lobaplatin in 0.9% sodium chloride injection was stable for 4 h when stored at 25, 37 and 42 ℃, while in 5% glucose injection lobaplatin was stable for 2 h at 25 and 37 ℃. The decomposition products of 1 were also studied by HPLC. Lactic acid was found when stored in both solution, and its content would increase along with time.

关 键 词：洛铂 0.9%氯化钠注射液 5%葡萄糖注射液 配伍稳定性 高效液相色谱 

分 类 号：R942[医药卫生—药剂学]