中药汤剂联合西药治疗肺间质纤维化的疗效分析及安全性评价  

Effect of Self-made Decoction Combined with Western Medicine Treatment of Pulmonary Interstitial Fibrosis and Its Safety Evaluation

作　　者：雷樟根 赵军飞[2] 

机构地区：[1]龙泉市人民医院,浙江龙泉323700 [2]丽水市人民医院,浙江丽水323000

出　　处：《中华中医药学刊》2015年第2期391-393,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生科技项目B类项目(2012KYB173)

摘　　要：目的:探讨肺间质纤维化患者应用自拟中药汤剂联合西药治疗临床疗效分析及其安全性评价,为临床诊断治疗提供参考。方法:将纳入98例肺间质纤维化患者根据随机数字表法随机分为对照组(n=49)和观察组(n=49);对照组给予西药治疗,观察组在西药治疗基础上结合自拟中药汤剂治疗;两组患者均以4周为1个疗程,2个疗程后评价其疗效及安全性。结果:观察组治疗后总有效率(89.80%)显著高于对照组(71.43%),且有显著性差异(P<0.05);观察组治疗后弥散功能和动脉氧分压显著高于治疗前,且有显著性差异(P<0.05);观察组治疗后FVC和FEV1明显高于治疗前及对照组治疗后,且差异具有统计学意义(P<0.05);两组患者治疗过程中均未出现明显的不良反应。结论:肺间质纤维化患者应用自拟中药汤剂联合西药治疗临床疗效显著,安全可靠,临床应用具有重要意义,值得进一步推广应用。Objective： To investigate the clinical efficacy and safety of self- made decoction combined with western medicine in the treatment of interstitial pulmonary fibrosis and to provide a reference for clinical diagnosis and treatment.Methods： 98 cases of pulmonary fibrosis,according to the random number table,were randomly divided into the control group（ n = 49） and the observation group（ n = 49）. The control group was given western medicine and the observation group used self- made decoction. Four weeks was a course of treatment and after two courses,we evaluated its efficacy and safety. Results： The total effective rate（ 89. 80%） in the observation group was significantly higher than that of the control group（ 71. 43%） after treatment and there was significant difference（ P〈0. 05）. The dispersion function and arterial partial pressure of the observation group were observed after treatment was significantly higher than those before treatment and there was significant difference（ P 〈0. 05）. The observation group ＇s FVC and FEV1 were significantly higher than those of the control group before treatment and after treatment and the difference was statistically significant（ P〈 0. 05）. Both groups had no obvious adverse reactions. Conclusion： The self- made decoction combined with western medicine has significant clinical efficacy,safety and reliability for patients with interstitial pulmonary fibrosis. The clinical application is of great significance,worthy of further promotion.

关 键 词：肺间质纤维化 自拟中药汤 西药 疗效 安全性 

分 类 号：R563[医药卫生—呼吸系统]