整合素介导的信号通路及在昆虫领域的研究进展  

Integrin-mediated Signaling Pathway and Its Research Advances in Insects

作　　者：张维博[1] 周其明 张奎[1] 杨丽群[1] 向仲怀[1] 崔红娟[1] 

机构地区：[1]家蚕基因组生物学国家重点实验室,西南大学,重庆400716 [2]河南省蚕业科学研究院,郑州450008

出　　处：《蚕业科学》2015年第1期159-165,共7页ACTA SERICOLOGICA SINICA

基　　金：高等学校博士学科点专项科研基金项目(博导类)(No.2-0130182110003);重庆市自然科学基金计划重点项目(No.cstc2013jcyjys0007);西南大学博士基金(含引进人才计划)项目(No.SWU111014)

摘　　要：整合素(integrin)是一类重要的细胞表面粘附分子,负责细胞内外信息的交流和转导。整合素在哺乳动物的各种正常生理活动,如免疫反应,细胞粘附与迁移,组织形成及修复,细胞的增殖、分化和凋亡等过程中扮演着重要角色,并且与疾病(如肿瘤、心血管疾病、肾脏疾病等)的发生和发展也密切相关。整合素在昆虫新陈代谢过程的多种生理生化反应中也发挥重要作用,目前果蝇(Drosophila melanogaster)、按蚊(Anopheles gambiae)、烟草天蛾(Manduca sexta)以及家蚕(Bombyx mori)等昆虫中的整合素已相继被鉴定,已有的研究显示整合素在昆虫的先天免疫,尤其是细胞免疫中担当重要角色。Integrins are important cell surface adhesion molecules,which are responsible for extra-and intra-cellular signal communication and transduction. Integrins are not only indispensable part in a variety of physiological activities in mammals,such as the immune response,cell adhesion and migration,tissue formation and repair,cell mitosis,differentiation and apoptosis process,but also closely related with occurrence and development of diseases,e. g.,tumor,cardiovascular disease and kidney disease. They also play an important role in various physiological and biochemical reactions of insect metabolic processes. Integrins have been identified from Drosophila melanogaster,Anopheles gambiae,Manduca sexta,and Bombyx mori. Existing researches on integrins have shown that they play important roles in insect innate immunity,especially in cellular immunity.

关 键 词：整合素 细胞粘附 信号转导 昆虫 免疫 肿瘤 

分 类 号：Q966[生物学—昆虫学]