姜黄素聚合物胶束的制备及体外评价  

Preparation of curcumin-loaded polymeric micelles and in vitro evaluation

作　　者：林晓[1] 典灵辉[1] 于恩江[1] 张振声[1] 

机构地区：[1]广东医学院药学院,广东东莞523808

出　　处：《中国医院药学杂志》2015年第3期213-216,共4页Chinese Journal of Hospital Pharmacy

基　　金：东莞市国际合作(编号:2013508152013);东莞市医疗卫生科技计划项目(编号:201410515200139);广东医学院博士启动项目(编号:BS201402);广东省高校青年创新人才项目(编号:2014LYM0003);广东医学院面上培育项目(编号:2014)

摘　　要：目的:制备姜黄素的Soluplus聚合物胶束,并对其进行体外评价。方法:采用薄膜分散法制备姜黄素聚合物胶束;采用粒径测定仪、透射电镜、X-射线衍射(XRD)对其进行表征;采用紫外分光光度法测定胶束的包封率和载药量;采用动态膜透析法考察载药胶束的体外释药特性。结果:薄膜分散法制备的胶束呈球形或类球形,平均粒径为(65.54±2.57)nm,平均包封率为(87.73±2.94)%,平均载药量(7.96±2.13)%;XRD结果表明姜黄素以无定型状态或分子状态包载在聚合物胶束中;体外释放结果表明姜黄素的soluplus聚合物胶束具有缓释作用。结论:该胶束制备工艺简单,其粒径、包封率、载药量可控,具有缓释作用。OBJECTIVE To prepare curcumin-loaded soluplus polymeric micelles（Cur-PMs）and perform evaluation in vitro.METHODS Cur-PMs were prepared by film dispersion method using an amphiphilic copolymer soluplus.The Cur-PMs were characterized by dynamic light scattering,transmission electron microscopy（TEM）,X-ray diffraction（XRD）.Entrapment efficiency（EE）and drug loading（DL）were determinated by UV.The release curve was determined by dialysis.RESULTSThe Cur-PMs observed by TEM were spherical with a mean particle size of（65.54±2.57）nm,the encapsulation efficiency and drug loading of Cur-PMs were（87.73±2.94）%and（7.96±2.13）%,respectively.X-ray diffraction showed that curcumin was in an amorphous or molecular form in the PMs.Release in vitro showed that Cur-PMs could slow down the release rate.CONCLUSION The preparation process is simple,with controllable particle size,entrapment efficiency and drug loading,and can delay drug release.

关 键 词：姜黄素 Soluplus 聚合物胶束 体外评价 

分 类 号：R943[医药卫生—药剂学]