氟伏沙明联合丁螺环酮治疗强迫障碍的效果观察  

The effect observation of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder

作　　者：陈海峰[1] 曹波[1] 李多聪[1] 陈海波[1] 

机构地区：[1]江西省吉安市第三人民医院精神科,江西吉安343000

出　　处：《中国当代医药》2015年第5期122-123,128,共3页China Modern Medicine

摘　　要：目的探讨氟伏沙明联合丁螺环酮治疗强迫障碍的临床效果。方法选取2012年3月～2014年3月来本院就诊的门诊和住院患者50例,将其随机分为研究组和对照组,每组25例,研究组服用氟伏沙明和丁螺环酮治疗,对照组单用氟伏沙明治疗,疗程为8周。治疗前及治疗后2、4、6、8周采用耶鲁-布朗强迫症状量表（Y-BOCS）、汉密顿焦虑量表（HAMA）进行评定,同时采用副反应量表（TESS）评定不良反应。结果两组总有效率差异无统计学意义（P〉0.05）。两组在治疗2、4、6、8周后Y-BOCS、HAMA评分均下降,4、6、8周末与治疗前比较,差异有统计学意义（P〈0.05）,研究组在治疗后6、8周末的评分与对照组比较,差异有统计学意义（P〈0.05）。两组不良反应发生率差异无统计学意义（P〉0.05）。结论氟伏沙明联合丁螺环酮治疗强迫障碍是安全有效的。Objective To explore the clinical efficacy of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder. Methods 50 patients with obsessive-compulsive disorder treated in our hospital from March 2012 to March 2014 were selected,and were randomly divided into research group （n=25） and control group （n=25）.Fluvoxamine and buspirone was given to the research group,while only fluvoxamine was given to the control group,the treatment course were 8 weeks.Yale-Brown obsessive compulsive sale （Y-BOCS）,Hamihon anxiety scale （HAMA） before and after treatment for 2,4,6,8 weeks was assessed,treatment emergent symptoms scale （TESS） was used to assess the side effects. Results There was no significant difference about the total effective rate between the two groups （P〉 0.05）.Y-BOCS,HAMA scores of both groups were decreased after treatment,scores had significant difference after 4,6,8 weeks treatment （P〈0.05）,while after 6,8 weeks treatment scores between the two groups had significant difference （P〈 0.05）.The incidence rate of side effects between the two groups had no significant difference （P〉0.05）. Conclusion Fluvoxamine combined with buspirone is safe and effective in treatment of obsessive-compulsive disorder.

关 键 词：强迫障碍 氟伏沙明 丁螺环酮 

分 类 号：R971[医药卫生—药品]