镇肝熄风汤对自发性高血压大鼠血压与胃肠动力的影响  

Effects of Zhengan Xifeng Decoction on Blood Pressure and Gastrointestinal Motility in Spontaneously Hypertensive Rats

作　　者：颜春鲁[1,2] 金华[1,3] 刘峰林[1] 窦荣海[1] 温鑫洋[1] 陈丽[1] 张秋菊[1] 徐厚谦[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]天津中医药大学,天津300193 [3]甘肃中医学院甘肃省中医方药挖掘与创新转化重点实验室,甘肃兰州730000

出　　处：《中国中医药信息杂志》2015年第3期69-72,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81160477);甘肃省自然科学研究基金计划(1107RJZA220);甘肃省高等学校基本科研业务费资助项目(2010-5)

摘　　要：目的探讨镇肝熄风汤对自发性高血压大鼠(SHR)血压与胃肠动力的影响。方法 15只WKY大鼠为空白组,90只SHR随机分为空白组、模型组、贝那普利组、氨氯地平组和中药高、中、低剂量组。空白组和模型组每日给予蒸馏水灌胃,各给药给予相应药物灌胃。干预8周后测定各组大鼠血压及胃残留率和小肠推进比。结果与空白组比较,模型组收缩压、舒张压和平均动脉压明显高于同周龄的WKY大鼠(P<0.05);与模型组比较,各给药组收缩压、舒张压和平均动脉压显著降低(P<0.05);与空白组比较,模型组大鼠胃残留率显著降低,小肠推进比显著升高(P<0.05);与模型组比较,中药高剂量组胃残留率显著升高,小肠推进比显著降低(P<0.05),其他给药组差异无统计学意义。结论镇肝熄风汤可降低SHR的血压,并能调节胃肠动力。Objective To explore the influencing mechanism of Zhengan Xifeng Decoction on blood pressure and gastrointestinal motility in SHR. Methods After 15 WKY and 90 SHR rats were were randomly divided into normal control group, model group, Benner Pury group, amlodipine group, Zhengan Xifeng Decoction high, middle, and low dose groups. The normal control group and model group were fed with distilled water daily. Rats in treatment group were administered with corresponding drugs daily. Blood pressure, gastric residual and intestinal propulsive ratio of rats was detected after eight-week intervention. Results Compared with the blank control group, systolic pressure, diastolic pressure, and mean arterial pressure were significantly higher than WKY rats of same age （P〈0.05）. Compared with the model group, the systolic pressure, diastolic pressure, and mean arterial pressure of treatment groups were significantly reduced （P〈0.05）. Compared with the blank control group, gastric residual rate of rats in the model group significantly decreased （P〈0.05）. Compared with the model group, the gastric residual rate in Zhengan Xifeng high dose group increased significantly, and intestinal propulsive ratio significantly increased （P〈0.05）, without statistical significance in the other treatment groups. Conclusion Zhengan Xifeng Decoction can reduce blood pressure in SHR, and regulate gastrointestinal motility.

关 键 词：镇肝熄风汤 自发性高血压大鼠 血压 胃肠动力 

分 类 号：R285.5[医药卫生—中药学]