水蛭抗肿瘤作用机制研究进展  

Research Progress in Studies on Antitumor Mechanisms of Leech

作　　者：季漪 李柳[2] 吴勉华[3] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029 [2]南京中医药大学中医内科急难症研究所,周仲瑛传承工作室,江苏南京210029 [3]南京中医药大学,江苏南京210029

出　　处：《中国中医药信息杂志》2015年第3期131-133,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81273717;81373511);国家自然科学基金青年基金(81102563);教育部高等学校博士学科点专项科研基金-博导类(20113237110001)

摘　　要：中药水蛭具有破血逐瘀消癥之功,一直以来用于治疗各种血瘀顽疾。随着现代药理学研究进展,水蛭在恶性肿瘤临床治疗中广泛应用,其抗肿瘤作用得到了许多临床及实验研究的证实。本文通过对国内外近年文献的分析、归纳和总结,从抑制肿瘤的生长和增殖、诱导肿瘤细胞凋亡、抑制肿瘤血管生成、抗血小板聚集和抗凝血作用、提高机体免疫力、抗肿瘤多药耐药性几方面归纳了水蛭的抗肿瘤作用机制,并指出目前研究中存在的不足和争议之处,希望能为临床应用及进一步研究提供思路。Leech has a broken blood stasis effect and has been used to eliminate a variety of stasis diseases. With the development of modern pharmacology study, in recent years, leeches are widely used in clinical cancer patients, and its anti-tumor effects have been confirmed by numerous clinical and experimental studies. Based on the latest domestic and foreign literature analysis and summary, this article discussed the antitumor mechanisms of leech from the following aspects：inhibition of tumor growth and proliferation, induction of tumor cell apoptosis, inhibition of tumor angiogenesis, anti-platelet aggregation and anti-clotting effect, improvement of immunity, and anti-tumor multi-drug resistance. It also pointed out deficiencies and controversy in current studies, with a purpose to provide ideas for further researches and clinical applications.

关 键 词：水蛭 抗肿瘤 作用机制 综述 

分 类 号：R285[医药卫生—中药学]