阿托伐他汀联合厄贝沙坦改善高血压患者的心血管重塑  

Therapeutic effect of atrovastatin combined irbesartan on cardiovascular remodeling in patients with hypertension

作　　者：李斌 陈原兵 郭娟 李玲 

机构地区：[1]西藏昌都地区人民医院内二科,西藏昌都854000 [2]西藏昌都地区人民医院急诊科,西藏昌都854000

出　　处：《心血管康复医学杂志》2015年第1期47-50,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:分析阿托伐他汀联合厄贝沙坦对原发性高血压(EH)患者动脉及心室重塑的改善作用。方法:选择我院的114例EH患者,依据治疗方案不同分为:厄贝沙坦组(72例,仅接受厄贝沙坦治疗);联合治疗组(42例,予以阿托伐他汀联合厄贝沙坦治疗)。治疗3月后,比较两组患者的颈动脉内膜-中膜厚度(IMT)、左室舒张末内径(LVEDd)、室间隔厚度(IVST)、左室后壁舒张末期厚度(LVPWTd),室壁运动积分指数(WMSI)及血压、血脂水平的差异。结果:与厄贝沙坦组相比,联合治疗组的IMT[(0.98±0.13)mm比(0.81±0.08)mm]、LVEDd[(55.2±3.9)mm比(43.3±2.8)mm]、IVST[(14.9±2.6)mm比(11.5±1.8)mm]及WMSI[(1.67±0.22)比(1.39±0.16)]显著降低(P<0.05);联合治疗组的血压[(144±12)/(94±8)mmHg比(136±16)/(86±8)mmHg]、总胆固醇[(5.87±0.96)mmol/L比(4.53±0.57)mmol/L]及低密度脂蛋白胆固醇[(3.46±0.59)mmol/L比(2.68±0.42)mmol/L]显著降低(P<0.05),高密度脂蛋白胆固醇[(0.87±0.13)mmol/L比(1.36±0.24)mmol/L]显著升高(P<0.05)。结论:应用阿托伐他汀联合厄贝沙坦能显著改善EH患者的血脂水平,动脉及心室重塑程度。Objective：To analyze the therapeutic effect of atorvastatin combined irbesartan on arterial and ventricular remodeling in patients with essential hypertension （EH）.Methods：A total of 114 EH patients of our hospital were selected.According to therapeutic protocol,they were divided into irbesartan group （n=72,only received irbesar-tan treatment）and combined treatment （n=42,received atorvastatin combined irbesartan therapy）.After three-month treatment,carotid intima-media thickness （IMT）,left ventricular end-diastolic diameter （LVEDd）,inter-ventricular septal thickness （IVST）,left ventricular end-diastolic posterior wall thickness （LVPWTd）and wall mo-tion score index （WMSI）were compared between two groups.Blood pressure and blood lipid levels were compared between two groups.Results：Compared with irbesartan group,there were significant reductions in IMT [（0.98± 0.13）mm vs.（0.81±0.08）mm],LVEDd [（55.2±3.9）mm vs.（43.3±2.8）mm],IVST [（14.9±2.6）mm vs. （11.5±1.8）mm]and WMSI [（1.67±0.22）vs.（1.39±0.16）],P 〈0.05 all;there were significant reductions in levels of blood pressure [（144±12）/ （94±8）mmHg vs.（136±16）/ （86±8）mmHg],total cholesterol [（5.87 ±0.96）mmol/L vs.（4.53±0.57）mmol/L]and low density lipoprotein cholesterol [（3.46±0.59）mmol/L vs. （2.68±0.42）mmol/L],P 〈0.05 all,and significant rise in level of high density lipoprotein cholesterol [（0.87± 0.13）mmol/L vs.（1.36±0.24）mmol/L,P 〈0.05]in combined treatment group.Conclusion：Atorvastatin com-bined irbesartan can significantly improve blood lipid,arterial and ventricular remodeling in EH patients.

关 键 词：高血压 心室重构 阿托伐他汀 厄贝沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]