Nrf2/ARE信号通路与肝脏疾病的研究进展  

Research progress on Nrf2/ARE pathway and liver diseases

作　　者：李春[1,2] 邓晔[1,2] 郭瑶雪[1,2] 颜苗[1] 彭文兴[1] 

机构地区：[1]中南大学湘雅二医院临床药学研究所,湖南长沙410011 [2]中南大学药学院,湖南长沙410013

出　　处：《中国医院药学杂志》2015年第4期363-366,共4页Chinese Journal of Hospital Pharmacy

摘　　要：对近几年关于Nrf2在各种肝脏疾病中作用的文献进行分析、归纳、总结,发现Nrf2/ARE信号通路的激活在防治病毒性肝炎、酒精性和非酒精性肝炎、胆汁淤积型肝损伤、肝纤维化、肝癌等肝脏疾病中起着重要作用。Nrf2/ARE通路在肝脏病理生理学过程中发挥重要作用,可能为防治肝脏疾病提供新的治疗靶点。We consult,analyse,conclude and summarize research progress of the role of Nrf2 in liver diseases in recent years,then found that Nrf2-ARE pathway collectively exhibits diverse biological functions against viral hepatitis,alcoholic and nonalcoholic liver disease,fibrosis,and cancer via target gene expression.The activation of Nrf2-ARE pathway plays a role in liver diseases,may provide a new therapeutic target to prevent and treat liver diseases.

关 键 词：NRF2 肝脏疾病 氧化应激 

分 类 号：R96[医药卫生—药理学]