脑出血患者血、尿β2-微球蛋白的变化及贝那普利对其的影响  

Changes of blood and urine β2-microglobulin of patients with cerebral hemorrhage and influences of benazaprii on it

作　　者：闫志群[1] 李六生[1] 谢希[1] 

机构地区：[1]三峡大学人民医院(湖北省宜昌市第一人民医院)肾内科,443000

出　　处：《中国实用医刊》2015年第5期22-23,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨脑出血患者血、尿β2-微球蛋白的变化及贝那普利对其的影响，了解贝那普利对脑出血患者肾脏的保护作用。方法将64例脑出血患者随机分成91那普利治疗组（n=32）和对照组（n=32），对照组予以常规治疗，治疗组在常规治疗的基础上服用91那普利10-20mg／d，疗程4周，观察治疗前后血压、尿素氮、血肌酐、血及尿β2-微球蛋白的浓度变化。结果贝那普利治疗组治疗后，血、尿β2-微球蛋白明显下降，与对照组比较差异有统计学意义（P〈0．05，P〈0．01）。结论贝那普利对脑出血早期肾脏损害具有保护作用。Objective To investigate the changes of blood and urine β2-microglobulin of patients with cerebral hemorrhage and influences of benazapril on it, and to understand functions of protecting renal of Benazapril for patients with cerebral hemorrhage. Methods Sixty-four cases cerebral hemorrhage were divided randomly into treatment group（n = 32） and control group （n = 32）. Treatment group was treated with benazapril 10 -20 mg/d on the basis of routine treatment, 4 weeks as a period of treatment. Around treatment, changes of blood pressure, urea nitrogen, blood creatinine, blood and urine β2-microglobulin were observed. Results After treatmen of benazapril group, blood and urine β2-microglobulin descended obviously, and had marked distinction after compared with control group （ P 〈 0. 05, P 〈 0. 01 ）. Conclusions Benazapril has protecting functions for cerebral hemorrhage complicated with early kidney injury.

关 键 词：脑出血 Β2-微球蛋白 贝那普利 

分 类 号：R587.1[医药卫生—内分泌]