香豆素-3-羧酸烟醇酯的合成  

Synthesis of Nicomethanol Coumarin-3-carboxylate

作　　者：李祥华[1] 吴亚先[1] 何黎琴[1] 

机构地区：[1]安徽中医药大学药学院,安徽合肥230031

出　　处：《安徽化工》2015年第1期34-35,41,共3页Anhui Chemical Industry

基　　金：安徽省教育厅自然科学重点科研项目(KJ2013A168)

摘　　要：目的:为寻找抗动脉粥样硬化药物,合成香豆素-3-羧酸烟醇酯。方法:以水杨醛、丙二酸二乙酯为原料,合成得到香豆素-3-羧酸,再在脱水剂作用下与烟醇缩合,得到目标化合物香豆素-3-羧酸烟醇酯。结果与结论:设计合成了香豆素-3-羧酸烟醇酯,目标物的化学结构经IR、MS、1H-NMR等确证。Objective： To search for effective antiatherogenic agent, Nicomethanol coumarm-^-carboxytate was synmeslzeo. Methods： Salicylide reacted with diethyl malonate under piperidine catalysis, then coumarin-3-carboxylic acid was gained through hydrolysis and acidification. The target compound was obtained by coupling coumarin-3-carboxylic acid with nicotinyl alcohol in the presence of dehydration agents. Results and Conclusion： Nicomethanol coumarin-3-carboxylate was synthesized. The chemical structure of the target compound was confirmed by IR, MS, and 1H-NMR spectra.

关 键 词：香豆素-3-羧酸 烟醇 合成 

分 类 号：O626.13[理学—有机化学]