糖尿病合并非创伤性骨折的发生部位和危险因素  

Risk factors and fracture site of diabetes mellitus combined with nontraumatic fracture

作　　者：陈玉凤[1] 郭献山[1] 王林栋[1] 赵建林[1] 耿秀琴[1] 张威[2] 

机构地区：[1]新乡市中心医院内分泌科,新乡453000 [2]新乡市中心医院骨科,新乡453000

出　　处：《郑州大学学报（医学版）》2015年第1期138-141,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的：探讨糖尿病合并非创伤性骨折患者的骨折部位和相关危险因素。方法：147例2型糖尿病患者分为非创伤性骨折组（骨折组）72例和无骨折组（对照组）75例。比较两组患者的年龄、性别、体重指数、病程、空腹血糖、糖化血红蛋白、血糖控制方法、中风及心脏病史、既往骨折病情况,糖尿病视网膜病变、糖尿病周围神经病变、骨密度（BMD）。采用logistic回归分析方法分析非创伤性骨折的危险因素。结果：72例骨折病例中,髋部是最常见的骨折部位（31.6%）。骨折组患者伴有糖尿病视网膜病变、糖尿病周围神经病变、中风病史、既往骨折病史的发生率高于对照组（χ2=4.461、16.642、4.140、7.771,P〈0.05）,BMD低于对照组（t=4.452,P=0.037）。Logistic回归分析结果提示既往骨折病史和糖尿病周围神经病变是骨折的独立危险因素（OR=3.800、10.419,95%CI=1.180-12.237、3.727-29.132）。结论：糖尿病合并非创伤性骨折中髋部骨折发生率最高,既往骨折病史和糖尿病周围神经病变是其发生的危险因素。Aim： To evaluate risk factors for non-traumatic fracture and the fracture site in patients with diabetes mellitus.Methods： A total of 147 patients with type 2 mellitus diabetes were divided into two groups： non-traumatic fracture group（ fracture group,72 cases） and non-fracture group（ control group,75 cases）.Age,gender,body mass index,duration of diabetes,fasting glucose,glycated hemoglobin,glycemic control methods,stroke,heart disease,and fracture history,diabetic retinopathy,diabetic peripheral neuropathy,and bone mineral density（ BMD） were compared between the two groups.The risk factors for non-traumatic fractures was analyzed by logistic regression analysis.Results： The hip was the most frequent fracture site（ 31.6%） in fracture group.Diabetic retinopathy,diabetic peripheral neuropathy,and history of stroke and fractures were more common in fracture group than in control group（ χ2= 4.461,16.642,4.140,7.771,P〈 0.05）.Fracture group had lower BMD（ t = 4.452,P = 0.037）.Logistic regression analysis showed that history of fracture and diabetic peripheral neuropathy were independent risk factors for non-traumatic fracture（ OR = 3.800,10.419,95% CI =1.180- 12.237,3.727- 29.132）.Conclusion： Hip fracture is the most common fracture in type 2 diabetes mellitus with non-traumatic fractures.Diabetic peripheral neuropathy is closely related to fracture.

关 键 词：2型糖尿病 非创伤性骨折 糖尿病周围神经病变 骨密度 危险因素 

分 类 号：R587.2[医药卫生—内分泌]