贝那普利联合氨氯地平治疗高血压的临床疗效分析  

Analysis of the Clinical Efficacy of Benazepril plus Amlodipine in the Treatment of Hypertension

作　　者：宋志强[1] 高强[1] 李梅[1] 李君[1] 郑秀海[1] 范鹰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院老年病科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2015年第4期714-717,共4页Progress in Modern Biomedicine

基　　金：黑龙江省科技厅国际合作项目(WB08B05)

摘　　要：目的:探讨贝那普利联用氨氯地平治疗高血压的临床疗效与安全性。方法:将90例高血压病患者随机分为3组,对照组1(n=30)给予贝那普利片治疗,对照组2(n=30)给予氨氯地平片治疗,观察组(n=30)给予贝那普利片联合氨氯地平片治疗,疗程12周,治疗前和治疗后12周,分析和比较各组患者的收缩压、舒张压、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇水平。结果:观察组的临床总疗效达93.3%,而对照组1和对照组2分别为63.3%、56.7%,均显著低于观察组(P<0.05)。经治疗后,观察组的血压降低程度较对照组1、对照组2更显著(P<0.05),而对照组1与对照组2之间比较无明显差别(P>0.05);观察组总胆固醇、甘油三酯、高密度脂蛋白胆固醇改善情况均显著优于对照组1、对照组2(P<0.05)。观察组不适症状的发生率为6.7%,显著低于对照组1(26.7%)和对照组2(23.3%),差异有统计学意义(P<0.05)。结论:贝那普利联合氨氯地平治疗高血压的疗效和安全性均显著优于单用贝那普利或氨氯地平,值得临床普及推广。Objective：To investigate the efficiency and safety ofbenazepril plus amlodipine in the clinical treatment of hypertension.Methods：90 patients with hypertension were randomly divided into the control group 1 （n=30） which was treated by benazepril alone,the control group 2（n=30） which was treated by amlodipine alone as well as the observation group （n=30） which was treated by benazepril and amlodipine for 12 weaks.The systolic blood pressure,diastolic blood pressure,serum total cholesterol,triglyceride,and high density lipoprotein cholesterol were detected and compared before treatment and 12 weeks after treatment.Results：After treatment,the total effective rate of observation group was 93.3%,which was significantly higher than those the control group 1（63.3%） and the control group 2 （56.7%）（P〈0.05）.The degree of blood pressure reduction of observation group was more significant compared with the control group 1 and controlgroup 2 （P〈0.05）,while there was no significant difference between the control group 1 and control group 2（P〉0.05）.The improvement of TC,TG and HDL-C of observation group were obviously better than those of the control group 1 and control group 2 （P〈0.05）.The incidence rate of adverse reactions was 6.7% in the observation group,which was significantly lower than those of the control group 1 （26.7%） and the control group 2（23.3%）（P〈0.05）.Conclusiom：The efficacy and safety of benazepril combined with amlodipine were evidently better than benazepril or amlodipine alone in the treatment of hypertension,which was worthy of clinical popularization.

关 键 词：贝那普利 氨氯地平 高血压 临床疗效 安全性 

分 类 号：R544.1[医药卫生—心血管疾病]