自身抗体引起的ABO血型正反定型结果不一致  

Positive and Negative Stereotypes Inconsistent in ABO Blood Group Caused by Autoantibody

作　　者：徐菲[1] 赵昕亚[1] 包进[1] 张瑞生[1] 

机构地区：[1]南京医科大学附属南京医院/南京市第一医院检验科,江苏南京210006

出　　处：《现代生物医学进展》2015年第5期858-860,共3页Progress in Modern Biomedicine

摘　　要：目的:对因自身抗体引起ABO血型正反定型结果不一致的疑难血标本进行血型鉴定和分析,探讨其原因和解决办法。方法:先用直接抗人球蛋白试验(DAT)和间接抗人球蛋白试验(IAT)确定ABO血型正反定型结果不一致的原因是由于自身抗体的存在,然后做吸收放散试验、抗体筛选试验等排除自身抗体的干扰以便血型的正确判定。结果:ABO血型正反定型结果不一致因自身抗体引起的有10例,其中温抗体7例,冷抗体3例,温抗体同时同种抗体阳性2例,冷抗体同时同种抗体阳性2例。结论:自身抗体会影响ABO血型的正确判定,选用合适的试验进行分析判断以提高血型鉴定的准确性。Objective： To analyze the dtfttedlt blood samples whose positive and negative stereotypes inconsistent in ABO bloodgroup caused by autoantibody, and to explore the reasons nad solutions. Methods： First, the reason of positive and negative stereotypesinconsistent in ABO blood group Was found to be the antibodies with DAT and IAT. Then absorption-elution test and antibody screening test was done to eliminate the interference of antoantibodies in order to determine blood type correctly. Results： Antibodies caused posi- tive and negative stereotypes inconsistent in ABO blood group in 10 eaes warm antibody type in 7 cases, cold antibody type in 3 cases, warm antibody combine irregular antibody in 2 cases, and cold antibody combine allo-antibody in 2 cases. Conclusions： Autoantibody can affect accurate judgment of ABO blood group, and appropriate tests should be chosen to improve the accuracy of the blood typing.

关 键 词：自身抗体 ABO血型 正反定型 

分 类 号：R55[医药卫生—血液循环系统疾病]