硝苯地平控释片联合替米沙坦对老年高血压患者动态血压及左室舒张功能的影响  

Effect of Nifedipine Controlled Release Tablets plus Telmisartan on the Ambulatory Blood Pressure Monitoring and Left Ventricular Diastolic Function of Elderly Patients with Hypertension

作　　者：杨红霞[1] 贺晓燕[1] 齐晓辉[1] 张彦丽[1] 戴剑峰[1] 

机构地区：[1]兰州军区机关门诊部,甘肃兰州730000

出　　处：《现代生物医学进展》2015年第5期866-869,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81170400)

摘　　要：目的：研究硝苯地平控释片联合替米沙坦对老年高血压患者动态血压以及左室舒张功能的影响。方法：选择我院2012年12月至2013年11月收治的轻、中度老年高血压合并左室舒张功能不全的患者84例为研究对象,并将其随机分为两组。对照组给予硝苯地平控释片30~60 mg/d,观察组在对照组的基础上,加用替米沙坦40 mg/d,降压未达疗效者,改为80 mg/d,疗程12周。期间观察和比较两组患者的动脉血压波动情况、左心室舒张功能及疗效。结果：对高血压的控制,观察组总有效率显著高于对照组（P〈0.05）,显效率高于对照组,但无统计学意义（P〉0.05）。动态血压监测及血压负荷结果提示两组治疗后的24 h收缩压平均值（24hm SBP）、24 h舒张压平均值（24hm DBP）、日间收缩压平均值（dm SBP）、日间舒张压平均值（dm DBP）、夜间收缩压平均值（nm SBP）、夜间舒张压平均值（nm DBP）均显著低于治疗前,且观察组显著优于对照组（P〈0.05）。两组的左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）、舒张期左室后壁厚度（LVPWD）、舒张期室间隔厚度（IVST）水平均较治疗前有所改善,但差异无统计学意义（P〉0.05）;观察组各指标水平优于对照组,但差异亦无统计学意义（P〉0.05）。结论：硝苯地平控释片联合替米沙坦治疗老年高血压有助于更加有效地控制其动态血压波动,且在一定程度上可改善左心室舒张功能。Objective： To investigate the effect of Nifedipine Controlled Release Tablets with Telmisartan Tablets on the ABP and left ventricular diastolic function of elderly hypertension. Methods： 84 mild or moderate elderly hypertension patients from December 2012 to November 2013 were divided into two groups randomly. The patients in control group took Nifedipine Controlled Release Tablets at 30-60mg/d. The observation group were dosed with 40 mg/d of Telmisartan Tablets. If the observation group failed to see the satisfactory drop, the dose of Telmisartan Tablets was adjusted to 80 mg/d. The whole research lasted for 12 weeks. The ABP and left ventricular diastolic fimction were observed and recorded during the research. Results： The total efficient rate of observation group was significantly higher than t the counterparts of control group （P〈0.05）. The excellent rate of observation group was higher than that of the other group（P〉0.05）. All the results of ABPM indexes and blood pressure load （including 24hmSBP, 24hmDBP, dmSBP, dmDBP, nmSBP, nmDBP） showed that both groups could control the fluctuation of blood pressure, while the observation group was superior to the control group（P〈0.05）. The results of left ventricular diastolic function （including LVEF, LVESD, LVEDD, LVPWD, IVST） indicated that both therapeutic schedule could improve the left ventricular diastolic function at certain extent. However, the differences between the two groups did not have statistical significance. Conclusion： To treat elderly hypertension with Nifedipine Controlled Release Tablets and Telmisartan Tablets could effectively control the fluctuation of blood pressure and improve left ventricular diastolic fi.mction to some extent.

关 键 词：硝苯地平控释片 替米沙坦 老年高血压 动态血压检测 心室舒张功能 

分 类 号：R544.1[医药卫生—心血管疾病]