红细胞分布宽度与ICU院内感染的相关性研究  

Correlation of Red Blood Cell Distribution Width and Nosocomial Infections in ICU

作　　者：常丽丽[1] 巩义春[2] 曹留霞 董丽娟[1] 马朋林[2] 

机构地区：[1]山西医科大学,山西太原030000 [2]解放军第309医院重症监护科,北京100000 [3]青岛医学院人体解剖与组织胚胎教研室,山东青岛266021

出　　处：《现代生物医学进展》2015年第5期915-917,932,共4页Progress in Modern Biomedicine

摘　　要：目的：探索红细胞分布宽度（RDW）与ICU院内感染的相关性。方法：根据2001年卫生部颁布的医院感染诊断标准,筛选出2011年1月至2013年12月在ICU住院发生院内感染的224例患者,与同期在ICU住院未发生院内感染的患者232例,收集相关临床资料[年龄、性别、既往合并高血压、冠心病史、慢性病（APACHEⅡ）评分、住院时间、预后]及RDW等实验室指标（连续收集入ICU前三天的实验指标取平均值）,分析RDW与院内感染发生的相关性。结果：与对照组RDW（12.18±1.08）%相比,院内感染组RDW（13.52±2.01）%明显升高,差异有统计学意义（P〈0.01）。多因素logistic回归分析显示,RDW是院内感染的独立预测因素（OR=4.75,95%CI：3.27~6.91,P〈0.01）。RDW界值为12.81%,RDW的ROC曲线下面积为（0.76±0.02）%,95%CI：0.71~0.80,诊断院内感染的敏感性为56.65%,特异性为85.75%。结论：RDW与ICU院内感染独立相关,是ICU院内感染的独立预测因素。Objective： To explore the correlation between red blood cell distribution width （RDW） and nosocomial infection in ICU. Methods： According to the diagnostic criteria of nosocomial infections issued by the Ministry of Health in 2001. Screened two hun- dred and twenty-four patients with nosocomial infections admitted to our hospital patients in the ICU from January 2011 to December 2013, with the same period, two hundred and thirteen patients without nosocomial infection in the ICU. Their clinical data [Age, Gender, Hypertension, Coronary heart disease, Chronic disease （APACHE Ⅱ ） score, Length of stay, the prognosis] and RDW et other laboratory indicators （The averaged value of experiments indicators were collected continuously into the ICU three days before） were recorded. An- alyzing the correlation between RDW and nosocomial infections in ICU. Results： The RDW in the group of nosocomial infection was （13.52 ± 2.01）%, it increased significantly compared with that in the control group （P〈0.01）. Multivariate logistic regression analysis showed that, the RDW was an independent predictor of nosocomial infection （OR=4.75, 95 % CI： 3.27 ~ 6.91, P〈0.01）. The RDW threshold value is 12.81 percent and the RDW area under the ROC curve was （0.76 ± 0.02） %, （95% CI： 0.71 - 0.80）, a diagnostic sensi- tivity was 56.65 % and a specificity was 85.75 % for the nosocomial infections in ICU. Conclusion： RDW is independently correlated with the nosocomial infections in ICU, and is thus an independent predictor for the nosocomial infections in ICU.

关 键 词：院内感染 红细胞分布宽度 ROC曲线 

分 类 号：R197[医药卫生—卫生事业管理]