CD4^+CD25^+Treg细胞在类风湿关节炎中的研究进展  

Research Progress of CD4^+CD25^+ Regulatory T Cells in Rheumatoid Arthritis

作　　者：赵艳宁[1] 杨帆[1] 彭静[1] 范雪梅[1] 李月[1] 元绍苓[1] 李洋[1] 

机构地区：[1]哈尔滨医科大学附属第二医院风湿免疫科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2015年第5期988-990,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(30972739)

摘　　要：调节性T细胞(Tregs)是近年来发现的一群具有免疫调节作用的CD4+T细胞亚群,如Th3、Tr1细胞等。因其能够产生多种具有免疫抑制作用的细胞因子而发挥其免疫负调节作用,不但在维持机体自身耐受方面发挥重要作用,在预防自身免疫性疾病方面也占据重要位置。其中CD4+CD25+Treg因其具有独特的作用方式及功能特征,而被学者广泛关注。近年来,关于CD4+CD25+Treg在类风湿关节炎(rheumatoid arthritis,RA)发病机制中的作用以及在RA治疗方面的应用也越来越受到人们的关注,认为其数目减少或功能失调与RA发病密切相关。RA是一种以关节破坏为主要表现的慢性炎症性疾病,病理早期主要表现为毛细血管生成,滑膜增生,后期主要表现为炎性细胞浸润,血管翳形成,并出现关节软骨以及骨的破坏,最终导致关节畸形及功能障碍。本文现将CD4+CD25+Treg与RA的研究进展做一综述。Regulatory T cells （Tregs） are a subset of CD4＋T cells with immune-regulatory function which were discovered in re- cent years, such as Th3 and Trl cells, the immunosuppressive effect can be exerted through prouducing a variety of immunosuppressive cytokines, which play an important role not only in maintaining the immune tolerance, but also in preventing autoimmune diseases. Among these Tregs, CD4＋CD25＋Tregs are widely concerned because of their unique mode of action and fimctional characteristics. In recent years, the effect of CD4＋CD25＋Tregs in the pathogenesis mechanism of RA and the use of CD4＋CD25＋Tregs in RA treatment has received wide public attention from people. It is considered that their decrease in the number or dysfunction is closely related to the pathogenesis of RA. RA is characterized by progressive joint damage. Early stages of disease progression are defined by capillary forma- tion, hyperplasia of the synovial membrane. Established RA exhibits cellular infiltration, pannus formation, cartilage degradation and bone erosion, and eventually induces the joint deformity and dysfunction. Here is a review of the research progress of CD4＋CD25＋Tregs in RA.

关 键 词：调节性T细胞 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]