Optimal aspect ratio of endocytosed spherocylindrical nanoparticle  

作　　者：Ying-Bing Chen Yan-Hui Liu Yah Zeng Wei Mao Lin Hu Zong-Liang Mao Hou-Qiang Xu 

机构地区：[1]Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China [2]Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang 550025, China [3]State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China [4]College of Civil Engineering, Guizhou University, Guiyang 550025, China

出　　处：《Frontiers of physics》2015年第1期119-123,共5页物理学前沿（英文版）

基　　金：Acknowledgements are made to the Na- tional Natural Science Foundation of China （Grant Nos. 11047022, 11204045, and 31360215）, the Research Foundation from Min- istry of Education of China （Grant No. 2012152）, Guizhou Provin- cial Tracking Key Program of Social Development （Grant Nos. SY20123089 and SZ20113069）, the Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education （Chongqing University）, and the Research Foundation for Young University Teachers from Guizhou Univer-sity （Grant No. 201311）.

摘　　要：Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.

关 键 词：cellular uptake depletion effects dimension of ligand-receptor complex elasticity theory 

分 类 号：Q513[生物学—生物化学] TB383[一般工业技术—材料科学与工程]