新型生物材料聚(β-苹果酸-co-β-羟基丁酸酯)的合成和结构表征  

Synthesis and Structural Characterization of New Biological Materials Poly(β-malicacid-co-β-butyrolactone)

作　　者：崔明凤 郭松岩[1] 周青[1] 乔友备[1] 范黎[1] 吴红[1] 

机构地区：[1]第四军医大学药学院药物分析学教研室,西安710032

出　　处：《材料导报》2015年第2期24-28,共5页Materials Reports

基　　金：国家自然科学基金(81271687)

摘　　要：以苯甲酸四乙铵为引发剂,引发β-苹果酸苄基内酯(MLABe)和β-丁内酯(BL)开环共聚,得到聚(β-苹果酸苄基酯-co-β-羟基丁酸酯)(P(MLABe-co-BL))共聚物。通过核磁共振氢谱(1 H-NMR)、核磁共振碳谱(13 CNMR)和红外光谱(FT-IR)表征,表明合成了聚合物单体MLABe和聚-β-羟基丁酸酯(PHB),为共聚奠定了基础。共聚实验结果表明,聚合物单体含量不同,聚合物组成有明显差别,分子量都在104以上。MLABe的竞聚率比BL的大,因此加入BL的比率越多,聚合时间就越长。MLABe和BL的比例为75/25(物质的量比),聚合时间短且共聚产物分子量适中,分布宽度窄。微观聚合机理表明MLABe和BL的比例为50/50(物质的量比)时,聚合过程酯交换剧烈,趋向于无规共聚。P(MLABe-co-BL)氢化苄基后得到两亲性共聚物聚(β-苹果酸-co-β-羟基丁酸酯)(P(MLA-coBL)),该共聚物改善了PMLA用作药物载体降解快、负电性大的缺点,有望在生物医用材料等方面得到应用。Poly（benzylβ-malolactone-co-β-butyrolactone）（P（MLABe-co-BL））was obtained by ring-opening polymerization of benzylβ-malolactone（MLABe）andβ-butyrolactone（BL）,using tetraethyl ammonium benzoic acid as initiator.Chemical structure of the polymer monomer and the polymer poly（β-hydroxybutyrate）（PHB）were characterized by ^1 H-NMR,^13 C-NMR and FT-IR,which laid the foundation for copolymerization reaction.Copolymerization results show that there is significant difference in the composition of polymerization products,due to the different proportions of content of monomers,and molecular weights are more than 10^4.The reactivity ratio of MLABe is larger than the BL,hence the more ratio of BL is added,the longer polymerization time is needed.The proportion of MLABe and BL is 75/25（mol/mol）,copolymerization products which have moderate molecular weight,narrow distribution width and obtained in short time.Scale of micro polymerization mechanism indicate that the proportion is 50/50（mol/mol）,which result in severe transesterification in the polymerization process,tends to random copolymerization.P（MLABe-co-BL）hydrogenated benzyl formed amphiphilic copolymer poly（β-malic acid-co-β-butyrolactone）（P（MLA-co-BL））.The copolymers overcome the shortcomings of PMLA as drug carrier,such as faster degradation and greater electronegativity,which is expected to be applied in biomedical materials.

关 键 词：β-苹果酸苄基内酯 β-羟基丁酸酯 共聚物 

分 类 号：TQ316.61[化学工程—高聚物工业]