变应性鼻炎患者血清IL-17和IL-23的表达及临床意义  

Significance of serum IL-17,IL-23 in patients with allergic rhinitis

作　　者：李良波[1] 谭君武[1] 彭洪[1] 龚成[1] 曹雪秋[1] 廖勇[1] 

机构地区：[1]湖北民族学院附属民大医院耳鼻咽喉头颈外科,恩施445000

出　　处：《中国免疫学杂志》2015年第2期247-249,共3页Chinese Journal of Immunology

摘　　要：目的:检测变应性鼻炎(Allergic rhinitis,AR)患者血清IL-17和IL-23的表达水平并探讨其临床意义。方法:检测25例AR患者(观察组)血清IL-17、IL-23、s Ig E(过敏原特异性Ig E)的表达水平,并以23名健康体检合格者(对照组)为对照,比较两组人群血清中IL-17、IL-23、s Ig E表达水平的差异,并探讨AR患者血清中IL-17、IL-23、s Ig E三者间的相互关系。结果:观察组患者血清中IL-17、IL-23及s Ig E水平均高于对照组(P均<0.01);观察组患者血清中IL-17、IL-23、s Ig E三者两两之间均呈线性正相关关系(P均<0.05)。结论:IL-17、IL-23参与了AR的发生发展过程,与s Ig E的形成可能有关。Objective：To explore the expression level of IL-17, IL-23 in patients with allergic rhinitis （AR） and their clinical significance. Methods： A total of 25 patients with AR were treated as observe group, and 23 healthy volunteers were chosen as the control group. The levels of serum IL-17, IL-23 and specific-IgE （s-IgE） were compared between the two groups. The relationships among serum IL-17 ,IL-23 and sIgE in patients with AR were discussed. Results： The levels of IL-17 ,IL-23 and sIgE in observe group were significantly higher than in control group. There was a positive linear correlation between the IL-17 and IL-23/the IL-23 and sIgE/ the sIgE and IL-17 in observe group. Conclusion： The IL-17, IL-23 might be the two important cytokine in the occurrence and development process of allergic rhinitis. The IL-17 ,IL-23 might be related to the formation of sIgE.

关 键 词：变应性鼻炎 IL-17 IL-23 

分 类 号：R446.62[医药卫生—诊断学]