呼吸道病毒特异性IgM检测对儿童呼吸道感染的指导意义  

Guiding significance of respiratory virus specific IgM in children with respiratory tract infection

作　　者：王加芬[1] 王凤秀[1] 郑媛媛[1] 马国英[1] 周红岩[1] 阚玉玲[1] 

机构地区：[1]山东省滨州市人民医院,滨州256600

出　　处：《中国免疫学杂志》2015年第2期257-260,共4页Chinese Journal of Immunology

摘　　要：目的：统计分析急性呼吸道感染患儿5种常见呼吸道病毒特异性Ig M的检出情况用以指导临床。方法：2012年1月~12月我院儿科住院急性呼吸道感染患儿1 609例,收集血清采用间接免疫荧光方法检测呼吸道合胞病毒（RSV）、腺病毒（ADV）、甲型流感病毒（IVA）、乙型流感病毒（IVB）、副流感病毒（PIV）特异性Ig M。结果：1 609例患儿检出阳性标本263例（16.35%）,IVB检出率最多,共136例（8.45%）,其余依次为IVA 63例（3.92%）、PIV 62例（3.85%）、ADV 44例（2.73%）、RSV 42例（2.61%）。不同年龄组患儿阳性标本检出率不同,差异具有统计学意义（χ2=134.822,P〈0.01）,随年龄增长阳性标本检出率逐渐增高,学龄期儿童检查率最高（34.55%）;IVB、PIV、IVA阳性标本检出率在不同年龄阶段的比较差异具有统计学意义（χ2分别为102.660、86.145、39.791,均P〈0.05）,IVB和IVA以学龄期儿童检查率为最高,分别达20.00%和8.64%,PIV以学龄前儿童检出率最高（12.07%）。不同呼吸道病毒Ig M阳性检出率在不同月份有各自的特点,IVB在3月和10月出现两个检出高峰,检出率分别达20.15%和11.11%;IVA在3月和5月出现两个检出高峰,检出率分别达10.27%和11.81%;PIV、RSV检出率在1~6月份平缓上升,在3月份检出率最高,分别达7.98%和6.46%,随后检出率又平稳下降;ADV在3、4、5三个月份检出率为最高,检出率达6.19%。结论：5种呼吸道病毒检出阳性率达16.35%,尤以IVB检出率为最高;呼吸道病毒特异性Ig M阳性检出率随年龄增长而逐渐增高,IVB和IVA以学龄期儿童感染率最高,而PIV以学龄前儿童感染率最高;5种呼吸道病毒感染在2012年有各自的流行特点。Objective：To statistics and analyze the detection rate of 5 kinds of common respiratory virus specific lgM in children with respiratory tract infection to guide the clinical. Methods： 1 609 cases of children with respiratory tract infection in department of Pediatrics in our hospital were collected in 2012 from 1 to 12 months. Serum was collected to detect the specific IgM of respiratory syncytial virus （ RSV）, adenovirus （ ADV）, influenza A virus （ IVA）, influenza B virus （IVB） and parainfluenza virus （PIV） by method of indirect immunofluorescence. Results： 263 positive cases were detected from 1 609 cases（ 16. 35% ）,and the positive rates of IVB was the highest（8.45% ） with a total of 136 cases,followed by the rest of IVA 63 cases（3.92% ） ,PIV 62 cases （3.85%） ,ADV 44 cases（2.73% ） and RSV 42 cases（2.61% ）. The positive detection rate was different in children of different age groups, and the difference was statistical significant （X2 = 134. 822, P〈0. 01 ）. Positive detection rate was gradually increased along with the age growth, and the detection rate of school-age children was the highest （34. 55% ） ;The comparison differences of IVB, PIV, IVA positive detection rate between different age stages were significant（x2 = 102. 660,86. 145,39. 791 ,P〈0. 05 ）. The detection rate of IVB and IVA was the highest in school-age children,20. 00% and 8.64% respectively. The detection rate of PIV was the highest（ 12. 07% ） in preschool children. The positive rates of different respiratory virus specific IgM had their own characteristics in different months. IVB appeared two positive peaks in March and October with the rate of 20. 15% and 11.11% respectively; IVA appeared two positive peaks in March and May with the rate of 10. 27% and 11.81% respectively; PIV and RSV , the detection rate of which was the highest （7. 98% and 6. 46 respectively） in March increased gently from January to June,and then declined steadily. The detection rate of ADV was the

关 键 词：儿童 呼吸道感染 免疫球蛋白M 间接免疫荧光法 

分 类 号：R392.7[医药卫生—免疫学]