骨愈搽剂的质量控制研究  

Preparation and Quality Control of Guyu Liniment

作　　者：赵淑慧 高瑛 陆洋[2] 温然[2] 

机构地区：[1]北京中医医院顺义医院,北京101300 [2]北京中医药大学中药学院,北京100102

出　　处：《世界中医药》2015年第1期104-106,109,共4页World Chinese Medicine

基　　金：北京市中医药科技项目(编号:JJ2011-36)

摘　　要：目的:制备骨愈搽剂并对其质量进行检查。方法:根据前期工艺研究结果进行中试生产制备骨愈搽剂,采用紫外分光光度法测定骨愈搽剂中总黄酮含量;采用薄层色谱法鉴别鸡血藤、伸筋草、花椒;进行装量差异、相对密度、p H值、微生物、稳定性等项目的检查。结果:中试提取条件为70%乙醇,10倍量,回流1 h,提取3次;鸡血藤、伸筋草、花椒照薄层色谱法,点样于硅胶G薄层板,展开,检视,均与对照品色谱相应位置上显相同颜色的荧光斑点;以芦丁为对照品,采用紫外分光光度法,在511 nm处测定骨愈搽剂中总黄酮含量为6.95 g/瓶;装量差异符合相关要求;样品在室温下留样观察,在6个月内质量稳定。结论:本制剂制备工艺简便,质量稳定可控。Objective：To prepare the Guyu liniment and to establish the quality control method for this medicine.Methods：Ac-cording to the previous studies to prepare the Guyu liniment, UV spectrophotometry was used to determine the content of total fla-vonoids in Guyu liniment.TLC was used to identify Spatholobi Caulis, Lycopodii Herba and Zanthoxyli Pericarpium in the pre-scription of Guyu liniment.The content uniformity, relative density, pH, microbe and stability of Guyu liniment were measured. Results：The preparation technology of Guyu liniment is simple.The quality of Guyu liniment is stable and controllable.

关 键 词：骨愈搽剂 总黄酮 质量控制 

分 类 号：R283[医药卫生—中药学] R284.2[医药卫生—中医学]