亚甲蓝在机械通气患者胃反流误吸监测中的应用  

Application of methylene blue to monitoring of gastro-oesophageal reflux and pulmonary aspiration in mechanically ventilated patients

作　　者：张丹羽[1] 王卫华[1] 谢丽[1] 

机构地区：[1]北京安贞医院抢救中心,北京100029

出　　处：《护理学杂志》2015年第4期14-16,共3页

摘　　要：目的探讨亚甲蓝标记法在诊断机械通气患者胃反流误吸中的可行性和实用性。方法将亚甲蓝注入200例机械通气患者的鼻饲营养液内标记染色;遵循按需吸痰原则,吸出患者气道分泌物后,分别进行痰液颜色的肉眼观察和胃蛋白酶检测,判断患者是否发生胃反流误吸。比较两种方法检测效果,对亚甲蓝标记法的敏感度、特异度进行分析。结果两种检测方法阳性率比较,差异无统计学意义(P>0.05);亚甲蓝标记法观察胃反流误吸敏感度为100%,特异度为98.26%。结论亚甲蓝标记法可用于机械通气患者胃反流误吸的诊断。Objective To explore the feasibility and practicability of methylene blue for monitoring of gastro-oesophageal reflux（GOR）and pulmonary aspiration in mechanically ventilated patients.Methods Methylene blue was injected in enteral nutrition solutions,then the solutions were provided through nasal feeding tube to 200 patients with mechanical ventilation.Endotracheal suctioning was performed following the principle of suctioning only as needed,and the color of the sputum was observed with naked eyes and pepsin detection was employed to determine whether patients developed GOR or pulmonary aspiration.The sensitivity and specificity of methylene blue for GOR and aspiration monitoring was calculated.Results The positive rate of GOR and aspiration detected by the two methods had no significant difference（P0.05）.The sensitivity of methylene blue was 100% and the specificity was 98.26%.Conclusion Methylene blue can be used for detecting GOR and aspiration in mechanically ventilated patients.

关 键 词：机械通气 肠内营养 胃反流 误吸 亚甲蓝 胃蛋白酶 临床实验 

分 类 号：R473.6[医药卫生—护理学] R573[医药卫生—临床医学]