生物胶对兔肾脏创伤出血治疗效果的研究  

Study of hemostatic function of biological glue on renal trauma in rabbit

作　　者：李传贵[1] 宋波[1] 郑宗钊 张银甫[1] 黄赤兵[1] 

机构地区：[1]第三军医大学新桥医院泌尿外科,重庆400037

出　　处：《重庆医学》2015年第6期743-745,共3页Chongqing medicine

摘　　要：目的观察生物胶在肾创伤出血中的止血效果。方法建立家兔肾划伤、肾部分切除伤和肾贯通伤模型,分别用生物胶和速效止血粉处理,观察记录出血量和止血时间。术后1个月取肾创面进行病理学检测,观察创面愈合情况。结果生物胶粘合伤口的止血效果明显优于速效止血粉,肾划伤模型中生物胶组和速效止血粉组出血量分别是(1.39±0.09)mL,(1.77±0.44)mL,差异无统计学意义(P=0.115);止血时间分别为(5.02±0.23)s、(66.40±7.35)s,差异有统计学意义(P<0.01)。肾部分切除伤及肾贯通伤模型中生物胶和速效止血粉两组中出血量分别是(2.07±0.25)mL、(11.42±1.33)mL,(2.01±0.36)mL、(3.95±0.39)mL,止血时间是(6.16±0.69)s、(139.38±8.97)s,(7.68±0.80)s、(144.26±9.27)s,差异均有统计学意义(P<0.01)。病理提示生物胶创面修复良好。结论生物胶对肾脏创伤的止血效果迅速且稳定,值得研究推广。Objective To investigate the hemostatic function of biological glue in renal trauma.Methods Establishment of rabbit kidney scratch,partial nephrectomy and renal injury penetrating wound models were available with a biological glue and hemostatic powder processing,observed and recorded the amount of bleeding and bleeding time.Tissue sample were transected from the wound of kidneys in each group after a month,and the renal wound healing condition was observed by pathological examination.Results The hemostatic function of biological glue was better than styptic powder,the amount of bleeding in biological glue group and hemostatic powder group of kidney scratched model were（1.39±0.09）mL,（1.77±0.44）mL,the difference was not statistically significant（P=0.115）;the bleeding time were（5.02±0.23）s,（66.40±7.35）s,the difference was statistically significant（P〈0.01）;the amount of bleeding in two models of partial nephrectomy and renal penetrating wound were（2.07±0.25）mL,（11.42±1.33）mL;（2.01±0.36）mL,（3.95±0.39）mL and bleeding time were（6.16±0.69）s,（139.38±8.97）s;（7.68±0.80）s,（144.26±9.27）s,the differences were statistically significant（P〈0.01）.Pathology results showed that the wounds healed well.Conclusion The hemostatic function of biological glue in renal trauma were remarkable and stable,and was worth to be further promoted.

关 键 词：止血 兔 生物胶 肾创伤 

分 类 号：R699.2[医药卫生—泌尿科学]