2型糖尿病患者动脉硬化程度的影响因素  

The Influencing factors of atherosclerosis degreee in patients with type 2 diabetes mellitus

作　　者：沈国飞 钱禹林 姚品芳 

机构地区：[1]吴江区中医医院,江苏苏州215221

出　　处：《现代医药卫生》2015年第5期676-678,681,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨2型糖尿病患者动脉硬化程度的影响因素。方法选取该院2011年1月至2014年9月初次诊断且未进行治疗的2型糖尿病患者116例,根据肱-踝脉搏波传导速度评价的动脉硬化程度分成正常组(39例)、轻度升高组(41例)、中度升高组(24例)、重度升高组(12例)四组,分析肥胖、高血压、血脂异常、高尿酸血症、血糖水平、γ-谷氨酰转肽酶(GGT)水平与动脉硬化程度的关系。结果四组患者高血压、血脂异常、高尿酸血症的发生率随着动脉硬化程度的加重而呈趋势性增加(χ2Trend=11.34、12.97、14.65,P<0.01)。四组血糖、GGT水平比较,差异均有统计学意义(F=15.45、7.23,P<0.01);高血压、血脂异常、高尿酸血症、血糖水平、GGT均是2型糖尿病患者动脉硬化程度的独立危险因素(OR=0.31、0.19、0.22、1.32、1.05,P<0.01)。结论除高血压、血脂异常、高尿酸血症、血糖水平外,GGT也是影响2型糖尿病患者动脉硬化主要因素。Objective To approach the influenceing factors of atherosclerosis degreee in patients with type 2 diabetes mellitus. Methods A total 116 untreated patients with type 2 diabetes mellitus patients from January 2011 to September 2014 were divided into the four groups including the normal group（39 cases）,the slightly-elevated group（41 cases）,the moderately elevated group（24 cases） and the severely elevated group（12 cases）. It was analyzed the correlations between the concentrations of the obesity,hypertension,dyslipidemia,hyperuricemia,blood glucose,gamma-glutamyltransferase（GGT） and the degree of atherosclerosis. Results The incidence of hypertension,dyslipidemia,and hyperuricemia became frequent with the acceleration atherosclerosis in the four groups（χ^2Trend=11.34,12.97,14.65,P〈0.01）. There were statistical significance in difference in concentrations of blood glucose and GGT. The obesity,hypertension,dyslipidemia,hyperuricemia,blood glucose and GGT were all independent influencing factors（OR =0.31,0.19,0.22,1.32,1.05,P〈0.01）. Conclusion Besides the obesity,hypertension,dyslipidemia,hyperuricemia,blood glucose,GGT concentration plays a major role in influencing the degree of arteriosclerosis.

关 键 词：糖尿病 2型 Γ-谷氨酰转移酶 动脉硬化 血压 血脂异常 尿酸 肱-踝脉搏波传导速度 

分 类 号：R587.1[医药卫生—内分泌]