右美托咪啶和氟哌啶醇联合治疗重症患者谵妄的临床对照研究  

Prospective comparative study on treatment of delirium in critically ill patients by using dexmedetomidine combined with haloperidol

作　　者：杨晟[1] 翁金森[1] 

机构地区：[1]福建省肿瘤医院ICU科,福州350014

出　　处：《福建医药杂志》2015年第1期79-81,共3页Fujian Medical Journal

摘　　要：目的评价右美托咪啶和氟哌啶醇联合治疗重症患者谵妄的疗效和安全性。方法将124例ICU住院谵妄患者随机分为观察组和对照组,每组62例。观察组患者采用右美托咪啶和氟哌啶醇联合治疗;对照组仅采用氟哌啶醇治疗。比较两组治疗的平均病程时间,并应用谵妄评定方法中文修订版(CAM-CR)、临床总体印象量表病情严重程度(CGI-SI),在治疗前及治疗后24、48、72h共4个时间点给予评分,综合比较疗效;比较两组患者的不良反应率。结果两组药物治疗谵妄均有效,观察组平均病程时间短于对照组,治疗后48h、72h的CAM-CR评分和CGI-SI评分优于对照组,差异有统计学意义;观察组不良反应率低于对照组,差异有统计学意义。结论右美托咪啶与氟哌啶醇联合应用治疗重症患者谵妄的疗效和安全性均优于单用氟哌啶醇治疗。Objective To compare the efficacy and safety of treatment by using haloperidol and the treatment by using dexmedetomidine combined with haloperidol,in critically ill patients with delirium.Methods A total of 124 patients of delirium in ICU were randomly divided into two groups：observational group（n=62）and control group（n=62）.The patients in observational group were treated by using dexmedetomidine combined with haloperidol;the patients in control group were treated by using haloperidol.The effect was measured by overall treatment time.The assessment of efficacy was made with confusion assessment method-Chinese reversion（CAM-CR）and clinical global impression scale-severity of illness（CGI-SI）before therapy,and 24 h,48h,72 hafter therapy.The total incidence rate of side effects was used to evaluate safety.Results Overall treatment time in observational group was shorter than that in control group.CAM-CR scores and CGI-SI scores of observational group were reduced significantly.The total incidence rate of side effect in observational group was lower than that in control group,which had significant difference.Conclusion The treatment of delirium by using dexmedetomidine combined with haloperidol is better than using haloperidol in terms of efficacy and safety.

关 键 词：谵妄 右美托咪啶 氟哌啶醇 

分 类 号：R459.7[医药卫生—急诊医学]