过敏性鼻炎患者主客观指标的相关性研究  

Correlation of subjective and objective indicators in children with allergic rhinitis

作　　者：陈光媚[1] 杨桂梅[1] 陈奕辉[1] 

机构地区：[1]海口市人民医院耳鼻咽喉科,海南海口570208

出　　处：《海南医学》2015年第3期366-368,共3页Hainan Medical Journal

摘　　要：目的探讨儿童过敏性鼻炎患者的血清变应原特异性lg E(slg E)水平、皮肤点刺试验(SPT)及外周血嗜酸性粒细胞(EOS)计数、血清嗜酸粒细胞阳离子蛋白(ECP)、血清总Ig E(tlg E)与鼻部症状视觉模拟量表评分(VAS)的相关性。方法选取2013年1月至2014年4月在我科就诊的过敏性鼻炎儿童患者58例,采用VAS对患者的病情严重度进行评价;应用国际标准方法做过敏原皮肤点刺试验,对所有病例检测外周血EOS计数,采用Um CAPl00系统测定血清ECP、tlg E和slg E水平;用Pearson相关分析对结果进行分析。结果血清s Ig E和皮肤点刺试验显著正相关(r=0.532,P<0.05);EOS计数与血清slg E之间具有显著相关性(r=0.3843,P<0.05),而与皮肤点刺实验阳性强度无显著相关性(r=0.182,P>0.05)。血清ECP水平与鼻塞症状VAS评分呈正相关(r=0.196,P=0.022),但与病情总体严重程度VAS评分无相关性(P>0.05)。血清s Ig E、SPT与鼻部症状VAS总分及EOS计数均无明显相关性(P>0.05)。结论皮肤点刺试验、血清s Ig E水平、血清总Ig E、外周血EOS计数与病情总体严重程度VAS评分均未见相关性,但连续动态的血清s Ig E、皮肤点刺试验、ECP可作为症状体征评分的补充。Objective To investigate the correlation of serum allergen-specificlg E（slg E） levels, skin prick test（SPT） and peripheral blood eosinophils（EOS） count, serum eosinophil cationic protein（ECP）, serum total Ig E（tlg E） with nasal symptoms visual analog scale score（VAS） in children with allergic rhinitis. Methods Fifty-eight children of allergic rhinitis admitted in our department for January 2013 to April 2014 were enrolled. VAS was applied to evaluate the severity of the patient＇s condition. International standard method was used to perform allergen skin prick tests. All the patients were detected for peripheral blood EOS counts, as well as serum ECP, tlg E and slg E levels by Um CAPl00 system. Pearson correlation analysis was applied to analyze the results. Results The serum s Ig E and skin prick tests showed a significant positive correlation（r=0.532, P〈0.05）. Peripheral blood eosinophils was significantly correlated with serum s Ig E（r=0.3843, P〈0.05）, but not with the positive strength of skin prick test（r=0.182, P〈0.05）. Serum ECP levels were positively correlated with nasal symptoms VAS scores（r=0.196, P=0.022）, but not with the overall illness severity VAS score（P〉0.05）. There was no significant correlation between serum s Ig E, SPT and nasal symptoms VAS score, peripheral blood eosinophil counts（P〉0.05）. Conclusion There is no correlation between skin prick test, serum s Ig E levels, serum total Ig E, peripheral blood counts, and EOS overall severity of illness VAS scores, but the continuous dynamic of serum s Ig E, skin prick tests, ECP can be used as supplements for sign and symptom score.

关 键 词：过敏性鼻炎 症状评分 血清特异性lg E 皮肤点刺试验 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]