不同血小板预防性输注阈值对血液病患者的影响  

The Impact of Different Threshold of Prophylactic Platelet Transfusion on Patients with Hematologic Disease

作　　者：吕颖[1] 孙桂香[1] 庄远[1] 陈麟凤[1] 席朝运[1] 封彦楠 王彦[1] 汪德清[1] 

机构地区：[1]解放军总医院输血科解放军临床输血中心,北京100853

出　　处：《标记免疫分析与临床》2015年第2期89-91,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的分析血液病患者预防性输注血小板阈值的输注效果与其他影响,为血液病患者输注血小板阈值的确定提供依据。方法将符合条件的患者分为两组:通过输注血小板,A组患者维持在≥10×109/L,B组维持在≥20×109/L,比较出血改善情况、输血效果、血小板抗体产生的比例。结果 A组患者输注次数、输注剂量、抗体阳性率明显低于B组,但是输注有效例次的比例明显高于B组患者,并且差异有统计学意义。两组的出血情况差异没有统计学意义。结论对病情稳定、血小板计数低于10×109/L且无明显危险因素的血液病患者,采用10×109/L作为预防性血小板输注的阈值是安全的。Objective To provide the basis for determining the threshold of prophylactic platelet transfusion of on patients with hematologic disease by analyzing the impact of different threshold of prophylactic platelet transfusion on patients. Methods The eligible patients were divided into two groups based on the platelet counts of patients after platelets transfusion,in group A platelet counts remained at ≥10 × 109/ L,in group B it maintained at ≥20 × 109/ L. The improvement of bleeding,blood transfusion effect and the proportion of produced platelet antibodies in both groups were compared. Results The infusion numbers,the dose of infusion and the rates of produced platelet antibodies in group A were all lower than that of patients in group B.However,there was no significantly difference on the bleeding between two groups. Conclusion For these stable patients with hematologic diseases and no obvious risk factors,using 10 × 109/ L trigger as a prophylactic platelet transfusion threshold might be safe.

关 键 词：血液病 预防性血小板输注 阈值 疗效 出血 

分 类 号：R552[医药卫生—血液循环系统疾病]