2型糖尿病合并冠心病患者血清SPARC水平与冠状动脉病变的关系  

Association of serum SPARC level with severity of coronary artery lesion in type 2diabetic patients with coronary heart disease

作　　者：王政[1,2] 宋海燕[1,2] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科 [2]哈尔滨医科大学激素与内分泌疾病重点实验室,黑龙江哈尔滨150086

出　　处：《临床荟萃》2015年第2期174-178,共5页Clinical Focus

基　　金：国家自然科学基金(81370903);黑龙江省留学归国人员基金(LC06C23)

摘　　要：目的探讨2型糖尿病合并冠心病患者血清中富含半胱氨酸的酸性分泌蛋白(SPARC)水平变化及与冠状动脉病变的关系。方法选取120例患者作为研究对象,采用酶联免疫吸附实验(ELISA)检测血清SPARC水平,应用Gensini积分评价冠状动脉病变程度。A组为健康对照组40例,根据造影结果和1999年世界卫生组织(WHO)糖尿病诊断标准将患者分为B、C、D组:其中B组(单纯2型糖尿病组)40例、C组(单纯冠心病组)40例、D组(2型糖尿病合并冠心病组)40例。结果 1B组、C组和D组血清SPARC水平高于A组(4.22±1.19)μg/L、(3.71±1.05)μg/L、(5.96±1.40)μg/L vs(3.60±0.40)μg/L(P均<0.05),其中D组血清SPARC水平最高(P<0.05)。2血清SPARC水平、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)是冠心病的影响因素。3D组血清SPARC水平与Gensini积分呈正相关(r=0.770,P<0.05),C组SPARC水平与Gensini积分无相关性(r=0.520,P>0.05)。4 Pearson相关分析显示:甘油三酯(TG)、FINS、HOMA-IR与SPARC呈显著正相关(r分别为0.780、0.762、0.891,P均<0.05)。结论 2型糖尿病合并冠心病患者血清SPARC水平升高,并且与冠状动脉病变程度显著相关。Objective To investigate the association of serum SPARC level with the severity of coronary artery lesion in type 2diabetic patients with coronary heart disease.Methods Patients with type 2diabetic patients and coronary heart disease were enrolled in this study.According to the results of coronary angiography and the 1999 WHO diabetes criteria,patients were divided into three groups：T2DM patients（group B,n =40）,coronary heart disease patients（group C,n =40）and patients with T2 DM and coronary heart disease（group D,n =40）,40 healthy individuals were enrolled as healthy control group（group A）.Serum SPARC level of each subject was measured using ELISA and the severity of coronary atherosclerosis was evaluated by Gensini scoring.Results Compared with that in group A,the serum SPARC level in group B,C and D increased significantly（4.22±1.19）μg/L,（3.71±1.05）μg/L and（5.96±1.40）μg/L vs（3.60±0.40）μg/L（P〈0.05）.Moreover,the serum SPARC level in group D was remarkably higher than that of the other groups（P〈0.05）.Serum SPARC level,insuline resistance（IR）,and glycosylated hemoglobin（HbA1c）were the vital factors contributing to coronary heart disease.Serum SPARC level was positively correlated with the Gensini scores in group D（r=0.770,P〈0.05）,whereas it was not related to the Gensini scores in group C（r=0.520,P〉0.05）.Pearson correlation analysis showed that serum SPARC level was positively correlated with triglyceride,fasting insulin,Homeostasis Model Assessment for Insulin Resistance Index（r=0.780,0.762 and 0.891,respectively;P〈0.05）.Conclusion Serum SPARC level elevated in T2 DM patients with coronary heart disease,which was significantly correlated with the severity of coronary artery disease.

关 键 词：糖尿病 2型 冠心病 富含半胱氨酸蛋白质61 

分 类 号：R587.1[医药卫生—内分泌]