急性放射性皮炎外喷3%注射用重组人白介素-11的疗效观察  

Effectiveness of three percent topical spray injection with recombinant human interleukin-11 on acute radioactive dermatitis

作　　者：童芳[1] 刘群[1] 蔡博宁[1] 黄玉荣[1] 

机构地区：[1]解放军总医院放射治疗科,北京100853

出　　处：《解放军医学院学报》2015年第2期133-135,共3页Academic Journal of Chinese PLA Medical School

基　　金：国家高技术研究发展计划(863计划)(2012AA022701)~~

摘　　要：目的观察放射性皮炎外用3%注射用重组人白介素-11(recombinant human interleukin-11,rh IL-11)的临床疗效。方法将2013年1-9月在我科行放疗并发放射性皮炎患者140例随机分两组,试验组70例使用3%rh IL-11外喷皮炎创面,对照组70例使用康复新液外敷。结果用药48 h后试验组疼痛缓解效果、皮炎康复效果均优于对照组(P<0.05)。尤其体现在Ⅲ度放射性皮炎中,疼痛治疗效果试验组优于对照组(χ2=4.792,P=0.041)。实验组3 d康复效果显效率明显高于对照组(80%vs 32%,P=0.008)。试验组7 d康复效果有效率明显高于对照组(80%vs 30%,P=0.004)。结论放疗后≥Ⅱ度放射性皮炎局部外喷3%rh IL-11溶液,可减轻急性放射性皮炎症状,促进康复。Objective To observe the clinical effectiveness of three percent topical spray injection with recombinant human interleukin-11 on acute radioactive dermatitis. Methods One hundred and forty patients with acute radioactive dermatitis in our department from January to September in 2013 were randomly divided into test group （n=70） and control group （n=70）. Patients in the test group were treated with 3% vial recombinant human interleukin - 11 spray dermatitis wound, while patients in the control group were treated with rehabilitation new liquid gels. Results After 48 hours, pain relief effect and dermatitis rehabilitation effect of patients in the test group were better than those of control group （P 〈 0.05）, especially in grade III radioactive dermatitis （X^ 2= 4.792, P=0,041）. The 3 d dermatitis rehabilitation effect rate of the test group was significantly higher than that of control group （80% vs 32%, P--if）.008）, and the 7 d dermatitis rehabilitation effect rate of the test group was significantly higher than that of control group （80% vs 30%, P=0.004）. Conclusion Topical spray injection with recombinant human interleukin - 11 solution after radiotherapy in radioactive dermatitis （grade II and above） can alleviate the symptoms of acute radioactive dermatitis and promote the rehabilitation of acute radioactive dermatitis.

关 键 词：重组人白介素-11 放射性皮炎 护理 

分 类 号：R473.73[医药卫生—护理学]