高血压促进血管平滑肌细胞L型钙离子通道重塑的研究进展  

L-type calcium channels remodeling in vascular smooth muscle cell promoted by hypertension

作　　者：曾国伟 刘波 赵国政 石菲[3] 

机构地区：[1]解放军95072部队门诊部 [2]解放军95890部队 [3]第四军医大学航空航天生物动力学教研室

出　　处：《解放军医学院学报》2015年第2期190-192,共3页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81301681)~~

摘　　要：血管平滑肌细胞(vascular smooth muscle cells,VSMCs)表达多种离子通道,包括各型钙离子通道,其中L型电压依赖型钙离子通道(L-type voltage-dependent calcium channels,LTCC)对于调节微小动脉血管张力发挥着重要作用。高血压时动脉血管张力异常增高,这种血管张力的变化又会影响LTCC的功能和表达。本篇综述将重点阐述VSMCs上研究较为充分的LTCC。首先,简要介绍LTCC在血管功能调节方面的作用;其次,讨论高血压时VSMCs上LTCC功能和表达变化的最新研究;最后,根据现有研究阐述LTCC作为高血压治疗靶点的应用前景。Vascular smooth muscle cells （VSMCs） can express different types of ion channels, including various calcium channels. The L-type voltage-dependent calcium channels （LTCC） on the plasma membrane of VSMCs plays a pivotal role in modulating the vascular tone of small arteries and arterioles. The abnormally-elevated arterial tone observed in hypertension thus points to an aberrant expression and function of LTCC in the VSMCs. In this short review, the LTCC in VSMCs are focused. First, a brief overview on the physiological role of vascular LTCC in regulating arterial tone is provided, then the current understanding of the expression changes and regulation of LTCC in the vasculature during hypertension are discussed. At last, based on available proof-of-concept studies, the potential therapeutic approaches targeting LTCC in order to restore blood pressure to normotensive levels are described.

关 键 词：高血压 血管平滑肌 L型电压依赖型钙离子通道 基因治疗 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]