瑞舒伐他汀对不稳定型心绞痛患者血脂及高敏C反应蛋白水平的影响  

Effect of rosuvastatin on level of blood lipids and high-sensitivity C-reactive protein in patients with unstable angina pectoris

作　　者：周建军 

机构地区：[1]浙江省江山贝林医院药剂科,324100

出　　处：《中国医药》2015年第3期315-317,共3页China Medicine

摘　　要：目的探讨瑞舒伐他汀对不稳定型心绞痛（UAP）患者血脂及高敏C反应蛋白（hs—CRP）水平的影响。方法选取2013年8月至2014年8月在浙江省江山贝林医院住院接受治疗的UAP患者98例，采用完全随机分组的方法将患者分为观察组和对照组，各49例。对照组接受常规治疗，观察组在常规治疗的基础上同时给予瑞舒伐他汀。采用双抗体免疫比浊法测定患者血清中总胆固醇、三酰甘油、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）、hs—CRP的浓度，同时采用酶联免疫吸附测定试剂盒测定血清中血浆氨基末端B型脑钠肽前体（NT—proBNP）和同型半胱氨酸（Hcy）水平。治疗后13周，比较2组治疗效果及血清中总胆固醇、三酰甘油、LDL-C、HDL—C、hs—CRP、NT-proBNP及Hey水平变化情况。结果治疗后13周，观察组有效率高于对照组[93．9％（46／49）比79．6％（39／49）]，差异有统计学意义（Х^2=4．125，P〈0．05）；观察组血清中总胆固醇、三酰甘油、LDL-C均明显低于对照组[（4．01±0．26）、（2．04±0．37）、（2．28±0．43）mmol／L比（5．89±0．31）、（2．31±0．42）、（3．21±0.36）mmol／L]，HDL—C的浓度明显高于对照组[（1．89±0．25）mmol／L比（1．35±0．18）mmol／L]，差异均有统计学意义（均P〈0．05）；观察组血清中hs—CRP、Hcy、NT—proBNP的水平明显低于对照组[（2．5±0．7）mg／L、（11．5±3．7）mmol／L、（99±21）mg／L比（4．0±0．8）mg／L、（13．6±2．7）mmol／L、（321-±53）mg／L]，差异均有统计学意义（均P〈0．05）。结论瑞舒伐他汀可降低UAP患者血清中血脂及hs—CRP水平，改善患者临床治疗疗效。Objective To observe the effect of rosuvastatin on the level of fipids and high-sensitivity C-reactive protein（hs-CRP） in patients with unstable angina pectoris（UAP）. Methods Totally 98 UAP patients were divided into observation group and control group. The control group received routine treatment and the observation group received both the conventional treatment and rosuvastatin treatment. The levels of total cholesterol, three acylglycerin, low density lipoprotein cholesterol （LDL-C） , high density lipoprotein cholesterol（HDL-C） ,hs-CRP in serum were detected by double antibody immune turbidimetric method; the levels of serum plasma amino-terminal b-type natriuretic peptide precursor （NT-proBNP） and homocysteine （Hcy） were detected by ELISA kit. After treatment of 13 weeks, three aeyl glycerin, serum total cholesterol, LDL, HDL-C, hs-CRP, Hcy and NT-proBNP between two groups were observed. Results After treatment of 13 weeks, the effectiveness of control group was lower than that of observation group [ 79.6% （39/49） vs 93.9% （46/49） ] ;the difference was statistically significant （Х^2 =4. 125, P 〈0.05）. After treatment 13 of weeks, three acyl glycerin, serum total cholesterol and LDL-C in the observation group were significantly lower than these in the control group [ （ 4. 01 ± 0. 26 ） , （ 2. 04 ± 0. 37 ） , （ 2. 28 ± 0. 43 ） mmol/L vs （ 5.89 ± 0.31 ） , （ 2.31 ± 0.42 ） , （ 3.21 ± 0.36 ） mmol/L ] The concentration of HDL-C was significantly higher than that of the control group [ （ 1.89 ± 0.25 ） mmoL/L vs （ 1.35 ± 0.18 ） mmol/L] ; differences were statistically significant （ all P 〈 0.05 ）. After treatment of 13 weeks, CRP, Hey and NT-proBNP in observation group were significantly lower than those in the control group [ （2. 5 ± 0. 7 ） mg/L, （ 1l. 5 ± 3. 7 ） mmol/L,（99±21）mg/Lvs （4.0 ±0.8）mg/L,（13.6 ±2.7）retooL/L,（321 ±53）mg/L]; differences were statistically significant （ all P 〈 0.05 ）. Concl

关 键 词：心绞痛 不稳定型 瑞舒伐他汀 调血脂药 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]