维持性腹膜透析剂量与ESRD患者的饮食蛋白摄入总量、残肾功能、血尿素浓度关系探讨  

Investigation on the relation between the dosage of maintenance peritoneum dialysis and the total quantity of dietary protein intake,residual renal function、blood urea level in ESRD Patients

作　　者：单亦升[1,2] 许菲菲[1] 孙梅[1] 林凡[1] 

机构地区：[1]温州医科大学附属第一医院内科,浙江温州325000 [2]浙江省温州康宁医院内科,浙江温州325000

出　　处：《中国现代医生》2015年第5期10-13,共4页China Modern Doctor

基　　金：浙江省科学技术厅科技计划项目(2008C33029);浙江省温州市科学技术局项目(Y20060067)

摘　　要：目的探讨维持性腹膜透析剂量与ESRD患者的饮食蛋白摄入总量、残肾功能、血尿素浓度关系。方法回顾性分析我院ESRD患者的临床资料。通过Matlab 6.5软件作饮食蛋白摄入总量、残肾功能、血尿素浓度与维持性腹膜透析剂量的关系曲线。结果患者每天通过腹透液和尿液丢失的蛋白质氮平均为(0.94±0.48)g/d,氨基酸氮及其他形式的非尿素氮丢失分别为(0.51±0.12)g/d及(31.4±5.3)mg/(kg·d),与透析剂量的关系曲线显示,饮食蛋白摄入总量越多,残肾功能越差,血尿素浓度越高,则需要的透析剂量越大。结论在保证患者不会发生营养不良的前提下,适当控制饮食蛋白和水的摄入,保护残肾功能,维持适当的血尿素浓度,可以有效减少透析剂量,节约透析费用。Objective To investigate the relation between the dosage of maintenance peritoneum dialysis and the total quantity of dietary protein intake,residual renal function,blood urea level in ESRD Patients. Methods The clinical data of ESRD patients in our department were analyzed retrospectively. The relationship curve between the dosage of maintenance peritoneum dialysis and the total quantity of dietary protein intake, residual renal function, blood urea concentration were established through Matlab 6.5 software. Results Every day protein nitrogen average through the drain fluid loss and urine of patient was（0.94±0.48） g/d, and other forms of amino acid nitrogen of urea nitrogen loss, respectively was（0.51±0.12）g/d,（31.4±5.3）mg/（kg·d）. the relationship with dialysis dose curve showed that the more amount of dietary protein intake, the greater the dialysis dose. The poor residual renal function, the greater the dialysis dose. The higher the concentration of blood urea, the greater the dialysis dose. Conclusion On the premise of guarantee patient＇s nutrition, appropriate control the intake of dietary protein and water, protection of residual renal function, maintain proper blood urea concentration, can effectively reduce dialysis dose, cut down the cost of dialysis.

关 键 词：维持性腹膜透析 终末期肾病 蛋白摄入总量 残肾功能 血尿素浓度 

分 类 号：R459.5[医药卫生—治疗学]