低温治疗脑损伤的相关分子和细胞通路研究进展  

Molecular and cellular pathways of low temperature in treatment of brain injury

作　　者：陈帅[1] 黄克刚[1] 

机构地区：[1]广西壮族自治区钦州市第一人民医院重症医学科,广西钦州535000

出　　处：《中国现代医生》2015年第5期157-160,共4页China Modern Doctor

摘　　要：急性脑损伤发病机制尚未完全阐明,目前在临床上无特效治疗方法 ,病死率较高。低温能降低机体代谢,低温可以保护神经元免受损伤,阻滞神经胶质细胞的激活(尤其是小胶质细胞),缓解内皮和血脑屏障的功能障碍。另一方面,低温可以改变细胞内的信号通路、基因调控系统和细胞的微结构。本文就低温治疗脑损伤的相关分子和细胞通路的研究进展进行简要综述。It has not been fully elucidated to the pathogenesis of acute brain injury, which has high mortality rate. Low temperature can protect neurons, block glial cell activation（especially microglia） and alleviate the dysfunction of endothelium and blood brain barrier by reducing the metabolism. On the other hand, low temperature can change cellular signal pathways, gene regulatory system and cell micro-structure. In this review, we summed up there lated molecules and cellular pathways of low temperature to treat brain damage.

关 键 词：低温 急性脑损伤 脑保护 

分 类 号：R651[医药卫生—外科学]