非组蛋白甲基化研究进展  

Research progress in non-histone methylation

作　　者：聂茜[1] 陈荣[1] 舒亚南[1] 陈鹏[1] 吴珺[1] 韩梅[1] 

机构地区：[1]河北医科大学基础医学院生物化学与分子生物学教研室,石家庄050017

出　　处：《生命的化学》2015年第1期31-37,共7页Chemistry of Life

基　　金：国家自然科学基金项目(31271222);国家国际科技合作专项(2011DFA32700);河北省重点基础研究项目(13967706D)

摘　　要：蛋白质的翻译后修饰主要包括磷酸化、乙酰化、泛素化以及甲基化,在调节蛋白质结构和功能上起到重要作用。目前对于蛋白质甲基化研究最多的是组蛋白甲基化。除了组蛋白,赖氨酸、精氨酸甲基化也发生在非组蛋白。近年来,越来越多的非组蛋白甲基化被发现,非组蛋白甲基化在肿瘤发生发展中同样具有重要意义。本文就此方面的进展作简要概述。Posttranslational modifications of proteins mainly include protein phosphorylation, acetylation, ubiquitylation and methylation, which play essential roles in regulating protein structure and functions. In the present studies, the protein methylation mainly focused on histones. However, lysine and arginine methylation also occur in non-histone proteins. Recently, a growing number of non-histone protein methylation has been found. And the methylation of non-histone proteins are also important for regulation of protein functions and development of cancers. This review introduced the research progress in non-histone methylation.

关 键 词：非组蛋白 甲基化 赖氨酸甲基转移酶 精氨酸甲基转移酶 

分 类 号：Q51[生物学—生物化学]