动脉粥样硬化易损斑块形成和破裂的研究进展  

Mechanism of vulnerable plaque formation and rupture

作　　者：郑霞霞[1,2] 丁家望[1,2] 童晓红[1,2] 

机构地区：[1]三峡大学第一临床医学院 [2]宜昌市中心人民医院心内科,宜昌443003

出　　处：《生命的化学》2015年第1期51-56,共6页Chemistry of Life

摘　　要：动脉粥样硬化能导致斑块形成。随着疾病的进展,斑块发展和破裂会引起致死性冠状动脉血栓形成,表现为急性冠脉综合征。斑块破裂后,斑块内具有高度成血栓性的物质暴露在血液中,导致血栓形成。斑块破裂主要发生于薄帽纤维斑块。此外,未破裂的斑块也可以形成血栓。然而,斑块破裂的机制仍不太清楚。本文将讨论动脉粥样硬化斑块发生和发展机制、斑块是如何参与危及生命的血栓形成等问题。Atherosclerosis leads to the formation of plaque. After decades of progression, the 0evelopment and rupture of plaques may suddenly cause life-threatening coronary thrombosis presenting as an acute coronary syndrome. And the culprit morphology is plaque rupture with exposure of highly thrombogenic. Ruptures occur mainly among lesions defined as thin-cap fibroatheromas. Also the thrombi can form on lesions without rupture. However, the mechanisms involved in plaque rupture remain largely unknown. In this review, we have discussed the mechanisms of atherosclerotic plaque initiation and progression, and how plaques suddenly precipitate life-threatening thrombi.

关 键 词：动脉粥样硬化斑块 斑块形成 斑块破裂 血栓形成 

分 类 号：R543.5[医药卫生—心血管疾病]