在本科教学中加强非编码RNA知识介绍的必要性  

Necessity of strengthening introduction of non-coding RNA knowledge in college teaching

作　　者：郭俊明[1] 肖丙秀[1] 季林丹[1] 龚朝辉[1] 

机构地区：[1]宁波大学医学院生物化学与分子生物学研究所,宁波315211

出　　处：《生命的化学》2015年第1期128-132,共5页Chemistry of Life

基　　金：宁波大学教学研究项目(JYXMxjg201406;Xcgpy200930);宁波大学精品资源共享课程建设项目(NWL001);宁波市优秀网络课程建设项目(200301);浙江省精品课程建设项目(201108;201109);国家双语教学示范课程建设项目(GJSYJX08-1)

摘　　要：随着基因组学和转录组学的发展,人们对非编码RNA(non-coding RNA,nc RNA)结构与功能的认识越来越深入。RNA的重要性已不再仅仅以"是否能为蛋白质编码"或"是否与蛋白质合成有关"来体现,它们在复制、复制后、转录、转录后、翻译和翻译后以及表观遗传等多个层面调控基因的表达,体现出丰富多彩的生物学功能。笔者在介绍nc RNA的概念、分类和主要功能的基础上,结合对本科生《生物化学与分子生物学》相关课程现有教学内容的分析,建议高校应通过教材编写、课堂教学、实验指导和学生科研等环节增加nc RNA知识的介绍。With the developments of genomics and transcriptomics, we know more about the structure and functions of non-coding RNAs （ncRNAs）. RNAs＇ significances are no more determined only according to whether they code for proteins or whether they are associated with protein synthesis. They play multiple biological roles by regulating gene expression in several levels including replication, post-replication, transcrip- tional, post-transcriptional, translational, post-translational and epigenetic levels. In this article, we have introduced ncRNAs＇ concept, their classifications and functions. And then we have analyzed the teaching contents of biochemistry and molecular biology-associated curriculums. Finally, we have suggested that we should introduce more knowledge about ncRNAs through textbooks compilation, classroom teaching, experimental guidance, and college students＇ research innovation programs.

关 键 词：教学改革 教学内容 创新能力 非编码RNA 

分 类 号：Q522-4[生物学—生物化学] G642[文化科学—高等教育学]