他汀类药物预防结直肠肿瘤的Meta分析  

Statin use and the risk of colorectal neoplasm: a meta-analysis of 30 studies

作　　者：陈羽[1] 吴礼浩[1] 马伟钦[1] 何兴祥[1] 

机构地区：[1]广东药学院附属第一医院消化内科,510080

出　　处：《现代消化及介入诊疗》2014年第6期368-372,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：国家自然科学基金项目(61201437);广东省医学科研基金资助项目(B2011152)

摘　　要：目的系统评价他汀类药物对结直肠癌的发病率及病死率的影响。方法使用Medline等数据库收集他汀类药物与结直肠肿瘤相关的文献,筛选高质量文献,分别计算RR或OR值以及95%CI等,分析他汀类药物预防结直肠癌及结直肠腺瘤的作用,运用漏斗图评价发表偏倚。结果共纳入30项研究,研究对象2 417 713例。他汀类药物预防结直肠癌的森林图提示存在统计学差异(RR=0.87,95%CI:0.77-0.99,P=0.03),他汀类药物预防结直肠腺瘤的森林图不存在统计学差异(OR=0.61,95%CI:0.31-1.22,P=0.16),漏斗图分析各项研究未发现发表偏倚。结论他汀类药物对结直肠癌可能起到一定的化学预防作用,而对结直肠腺瘤的作用有待进一步研究。Objective Aim of this study is to explore the association between statin use and colorectal neoplasm risk through meta-analysis based on published studies. Methods A comprehensive literature search was undertaken through August 2014 looking for eligible studies through Medline and so on. Pooled relative risk （RR） estimates and 95%confidence intervals （CIs） were used to calculate estimated effect. Then, the po-tential presence of publication bias and study heterogeneity was assessed. Result A total of 30 studies, involv-ing 2,417,713 subjects, contributed to the analysis. Overall, statin use was associated with a modest reduction in the risk of colorectal cancer （RR=0.87, 95%CI：0.77-0.99, P=0.03）. However, we did not find significant evidence of statin use and colorectal adenoma （OR=0.61, 95%CI：0.31-1.22, P=0.16）. Publication bias was not be detected by the funnel plot. Conclusion Statin use was associated with a modest reduced risk of col-orectal cancer. However, further targeted research of the association between statin and colorectal adenoma is warranted.

关 键 词：他汀类药物 结直肠肿瘤 META分析 发病率 

分 类 号：R972.6[医药卫生—药品]